EVALUATION OF SERUM LEVELS OF OSTEOPONTIN AND BONE SIALOPROTEIN IN FEMALE PATIENTS WITH TENDINOPATHY
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Derman Medical Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The pathogenesis of tendinopathy remains unclear. Small integrin-binding ligand N-linked glycoproteins (SIBLING), a family of non-collagenous proteins including osteopontin (OPN) and bone sialoprotein (BSP), were initially thought to be limited to mineralized tissue, but recent studies have reported that they are more widely distributed and are expressed in non-mineralized tissues. The aim of this study was to investigate relationships between serum OPN and BSP levels and tendinopathy disease. Material and Method: 39 female tendinopathy patients and 39 female healthy volunteers were recruited for this prospective observational study. Serum OPN and BSP levels were measured using enzyme-linked immunosorbent assay. We also measured body mass index and erythrocyte sedimentation rate (ESR), white blood cells (WBC), and neutrophil-lymphocyte ratio (NLR). Results: There were no significant differences in serum BSP levels between the two groups (41.83 +/- 52.03 vs. 53.64 +/- 53.06 ng/mL, p=0.276). There were also no significant differences in serum OPN levels between the two groups (57.37 +/- 21.61 vs. 77.72 +/- 72.14 ng/mL, p=0.363). There were no significant differences in WBC, NLR, and ESR values between the two groups (p=0.897, p=0.795, p=0.405, respectively). There was no correlation between serum BSP levels and OPN, WBC, NLR, and ESR levels in the patient group. Patients with tendinopathy had a negative correlation between serum OPN levels and NLR levels. Discussion: The results of this study have indicated that BSP and OPN levels are not involved in the pathogenesis of tendinopathy.
Açıklama
Anahtar Kelimeler
Tendinopathy, Bone Sialoprotein, Osteopontin, Sibling Family
Kaynak
Journal of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
8
Sayı
4
