The Protective Effect of Ellagic Acid on Lung Damage Caused by Experimental Obstructive Jaundice Model

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dc.contributor.authorGul, M.
dc.contributor.authorAliosmanoglu, I.
dc.contributor.authorUslukaya, O.
dc.contributor.authorFirat, U.
dc.contributor.authorYuksel, H.
dc.contributor.authorGumus, M.
dc.contributor.authorUlger, B. V.
dc.date.accessioned2024-04-24T16:24:15Z
dc.date.available2024-04-24T16:24:15Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim : This study aimed to investigate protective effects of ellagic acid on lungs in an experimental obstructive jaundice model. Methods : Four groups were established, each consisting of ten randomly selected rats : Group 1: sham, Group 2: ellagic acid, Group 3 : obstructive jaundice, and Group 4 : obstructive jaundice + ellagic acid. Ellagic acid was administered orally at a dose of 60 mg/kg/day to group 2 and 4. The animals were sacrificed eight days later. The total oxidative status and the total antioxidant capacity in their lung tissue were determined, and malondialdehyde levels in their blood were measured. Histopathological changes in the lungs were examined. Results : In the obstructive jaundice group treated with ellagic acid, there was a decrease in malondialdehyde levels and a reduction in the total oxidative status and the oxidative stress index, whereas the total antioxidant capacity increased (p < 0.001). The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with the ellagic acid (p < 0.05). Conclusion : This study shows that ellagic acid has a protective effect against oxidative damage in lung tissue in obstructive jaundice.en_US
dc.identifier.doi10.1080/00015458.2013.11680929
dc.identifier.endpage289en_US
dc.identifier.issn0001-5458
dc.identifier.issue4en_US
dc.identifier.pmid24224439
dc.identifier.scopus2-s2.0-84883325376
dc.identifier.scopusqualityQ3
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2013.11680929
dc.identifier.urihttps://hdl.handle.net/11468/16607
dc.identifier.volume113en_US
dc.identifier.wosWOS:000324604300010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe Protective Effect of Ellagic Acid on Lung Damage Caused by Experimental Obstructive Jaundice Modelen_US
dc.titleThe Protective Effect of Ellagic Acid on Lung Damage Caused by Experimental Obstructive Jaundice Model
dc.typeArticleen_US

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