Clinical significance of increased serum neopterin in chronic kidney failure as a biomarker of cell-mediated immunity

Basit Öğe Kaydı
dc.contributor.authorÜnüvar, Songül
dc.contributor.authorAslanhan, Hamza
dc.date.accessioned2021-09-17T06:27:49Z
dc.date.available2021-09-17T06:27:49Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractBackground: Neopterin is a pyrazino-pyrimidine compound which is used as a marker of cell-mediated immunity in a variety of diseases. It is known that neopterin levels increase in diseases where interferon-gamma (IFN-g) stimulation is present, and also as a result of deficiencies in renal function, given that the primary means of elimination of neopterin is through the kidneys. In this study, we aimed to investigate the role of increased neopterin levels as a prognostic biomarker in patients with impaired renal function. Methods: A total of 90 individuals including 63 patients with chronic kidney failure (CKF) and 27 healthy volunteers were included in the study. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay. A Mann-Whitney U test and a Pearson Correlation Test were used in the statistical analysis, with a p value of <0.05 being considered statistically significant. Results: The mean age was 52.21±0.16 years in the patient group and 56.55±0.32 years in the control group. In the CKF patients, serum neopterin levels increased to a significantly greater degree than in the control group (p<0.001), while no statistically significant correlation was identified between serum neopterin levels and age (p>0.05). Conclusions: A significant increase was found in the serum neopterin levels in the CKF patients, due to both the triggering of the disease and the reduction of neopterin elimination.en_US
dc.description.abstractUvod: Neopterin je pirazino-pirimidinsko jedinjenje koje se koristi kao marker ćelijski posredovanog imuniteta kod različitih oboljenja. Poznato je da se nivoi neopterina povećavaju kod oboljenja gde je prisutna intreferon-gama stimulacija (IFN-g) i kao rezultat deficijencije kod bubrežne funkcije, tako sto se primarno neopterin eliminise kroz bubrege. U ovom izučavanju svrha je bila da se prouči uloga povećanih nivoa neopterina kao prognostičkog biomarkera u pacijenata sa ostećenom bubrežnom funkcijom. Metode: Proučavanje je obuhvatilo ukupno 90 osoba uključujući 63 pacijenata sa hroničnim bubrežnim ostećenjem (CKF) i 27 zdravih volontera. Koncentracije serumskog neopterina merene su primenom enzimskog-imunoodređivanja. Za statističku analizu korisćeni su Mann-Whitney U test i Pearson korelacioni test, sa p vrednosću < 0,05, kao statistički značajnom. Rezultati: Pacijenti su imali srednju prosečnu starost od 52,21 ±0,16 godina, a kontrolna grupa 56,55± 0,32. U CKF pacijenata serumski neopterin nivoi povećavali su se značajno vise nego u kontrolnoj grupi (p < 0,001), dok nije bilo statistički značajne korelacije koja je identifikovana između nivoa serumskog neopterina i godina starosti (p> 0,05). Zakljućak: Nađeno je značajno povećanje nivoa serumskog neopterina kod CKF pacijenata, kako zbog bolesti tako i zbog smanjenog izlučivanja neopterina.en_US
dc.identifier.citationÜnüvar, S. ve Aslanhan, H. (2019). Clinical significance of increased serum neopterin in chronic kidney failure as a biomarker of cell-mediated immunity. Journal of Medical Biochemistry, 38(1), 1-5.en_US
dc.identifier.doi10.2478/jomb-2018-0019en_US
dc.identifier.endpage5en_US
dc.identifier.issn1452-8258
dc.identifier.issue1en_US
dc.identifier.pmid30820177en_US
dc.identifier.scopus2-s2.0-85049224814en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://scindeks.ceon.rs/article.aspx?artid=1452-82581901001Q
dc.identifier.urihttps://hdl.handle.net/11468/7657
dc.identifier.volume38en_US
dc.identifier.wosWOS:000451080000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslanhan, Hamza
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofJournal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell-mediated immunityen_US
dc.subjectChronic kidney failureen_US
dc.subjectNeopterinen_US
dc.subjectRenal diseasesen_US
dc.subjectCelijski posredovani imuniteten_US
dc.subjectHronično bubrežno ostećenjeen_US
dc.subjectNeopterinen_US
dc.subjectBubrežno oboljenjeen_US
dc.titleClinical significance of increased serum neopterin in chronic kidney failure as a biomarker of cell-mediated immunityen_US
dc.title.alternativeKlini?ki zna?aj pove?anog serumskog neopterina u hroni?nom ošte?enju bubrega kao biomarker ?elijski posredovanog imunitetaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
CLINICAL SIGNIFICANCE OF INCREASED SERUM NEOPTERIN IN CHRONIC.pdf
Boyut:
67.5 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu