Phosphodiesterase-5 inhibitors may facilitate bone defect recovery

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dc.contributor.authorYaman, F.
dc.contributor.authorAtilgan, S.
dc.contributor.authorGunes, N.
dc.contributor.authorAgacayak, S.
dc.contributor.authorGunay, A.
dc.contributor.authorUcan, M. C.
dc.contributor.authorBakir, S.
dc.date.accessioned2024-04-24T17:37:45Z
dc.date.available2024-04-24T17:37:45Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives: Bone healing is still one of the most important problems of the oral and maxillofacial surgery procedures. This study was designed to evaluate the effect of sildenafil citrate (which is used for erectile dysfunction) on bone defect healing in an experimental animal model. Materials and Methods: A total of 42 male Wistar-albino rats were randomly assigned to the control group (n=21) or the study group (n=21). The control group was fed on a standard laboratory diet until 12 h before surgery, whereas the study group received Sildenafil citrate via orogastric tube 10 mg/kg once a day for 30 days. Under anaesthesia, a 3x3x2 mm depth defect was made on tibia of each rat. 7 animals from each group were euthanised on postoperative days 7,15 and 30. Bone samples were taken for examination, histologically on day 7, by 3D dental tomography on day 15, and for bone strength resistance on day 30. Results: Statistically significant differences were determined between the groups from the inflammatory and repair phase, with the healing process being more advanced in the Sildenafil group. Conclusions: Sildenafil citrate can be used as a supporting factor to accelerate the healing process of bone. In future comprehensive studies will need to demonstrate the Sildenafil citrate affect on bone defect healing.en_US
dc.description.sponsorshipExperimental Animals Research Clinic of Dicle Universityen_US
dc.description.sponsorshipWe thank to Dr. Mehmet Tuzcu pathologist at Adana Veterinary Control Research Institute and for support of Experimental Animals Research Clinic of Dicle University to this study.en_US
dc.identifier.endpage1305en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid22195363
dc.identifier.scopus2-s2.0-84855991437
dc.identifier.scopusqualityQ2
dc.identifier.startpage1301en_US
dc.identifier.urihttps://hdl.handle.net/11468/21163
dc.identifier.volume15en_US
dc.identifier.wosWOS:000297920800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSildenafil Citrateen_US
dc.subjectBone Healingen_US
dc.subjectOral And Maxillofacial Surgeryen_US
dc.titlePhosphodiesterase-5 inhibitors may facilitate bone defect recoveryen_US
dc.titlePhosphodiesterase-5 inhibitors may facilitate bone defect recovery
dc.typeArticleen_US

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