Sympathetic overactivity in patients with pulmonary stenosis and improvement after percutaneous balloon valvuloplasty

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dc.contributor.authorAlyan, Omer
dc.contributor.authorOzdemir, Ozcan
dc.contributor.authorKacmaz, Fehmi
dc.contributor.authorTopaloglu, Serkan
dc.contributor.authorOzbakir, Cemal
dc.contributor.authorGozu, Ayfer
dc.contributor.authorKorkmaz, Sule
dc.date.accessioned2024-04-24T17:11:37Z
dc.date.available2024-04-24T17:11:37Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Percutaneous balloon valvulotomy (PBV) is the procedure of choice for the treatment of valvular pulmonary stenosis (PS) with similar results comparable to surgical valvotomy but less invasive. . Methods and Results: Twenty-seven consecutive patients with PS being evaluated for PBV were enrolled in the study. Peak instantaneous transvalvular gradient, right ventricle (RV) diameter, mean atrial pressures, RV systolic pressure (RVSP), pro-brain natriuretic peptide (proBNP) levels significantly decreased immediately after PBV. Regarding heart rate variability (HRV) parameters, mean HR (heart rate), LF (low frequency) day and night, LF/HF day and night significantly decreased and standard deviation of all NN intervals (SDNN), root mean square of successive differences (RMSSD), P number of NN intervals that differed by more than 50 ms from adjacent interval divided by the total number of all NN intervals (PNN50), HF (High frequency) day and night significantly increased 1 day after PBV and these changes were shown to be preserved at the first month. The increase in SDNN was correlated with the decrease in right atrial pressure (RAP) (r = -0.5, P = 0.04); the increase in standard deviation of the 5-minute mean RR intervals (SDANN) was correlated with the decrease in proBNP (r = -0.4, P = 0.03). Conclusions: Sympathetic overactivity and increased proBNP levels were associated with the symptomatic status of patients with PS. Associated with a decrease in atrial pressures and proBNP levels, PBV yielded a decrease in adrenergic overactivity in the patients with PS.en_US
dc.identifier.doi10.1111/j.1542-474X.2008.00229.x
dc.identifier.endpage265en_US
dc.identifier.issn1082-720X
dc.identifier.issn1542-474X
dc.identifier.issue3en_US
dc.identifier.pmid18713326
dc.identifier.scopus2-s2.0-47249141676
dc.identifier.scopusqualityQ2
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1111/j.1542-474X.2008.00229.x
dc.identifier.urihttps://hdl.handle.net/11468/17635
dc.identifier.volume13en_US
dc.identifier.wosWOS:000257549900006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnnals of Noninvasive Electrocardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary Stenosisen_US
dc.subjectPercutaneous Balloon Valvulotomyen_US
dc.subjectHeart Rate Variabilityen_US
dc.titleSympathetic overactivity in patients with pulmonary stenosis and improvement after percutaneous balloon valvuloplastyen_US
dc.titleSympathetic overactivity in patients with pulmonary stenosis and improvement after percutaneous balloon valvuloplasty
dc.typeArticleen_US

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