Serum levels of leptin and homocysteine in women with polycystic ovary syndrome and its relationship to endocrine, clinical and metabolic parameters

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dc.contributor.authorAtamer, A.
dc.contributor.authorDemir, B.
dc.contributor.authorBayhan, G.
dc.contributor.authorAtamer, Y.
dc.contributor.authorIlhan, N.
dc.contributor.authorAkkus, Z.
dc.date.accessioned2024-04-24T17:14:42Z
dc.date.available2024-04-24T17:14:42Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description7th International Congress on Coronary Artery Disease -- OCT 07-10, 2007 -- Venice, ITALYen_US
dc.description.abstractWe examined the relationship between endocrine, clinical and metabolic parameters in 35 women (mean age 27.3 years) with polycystic ovary syndrome (PCOS) and 30 age- and body mass index-matched normal ovulatory women. In PCOS women, serum leptin, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3 levels and the insulin resistance index (HOMA-IR) were significantly higher, while sex hormone-binding globulin and high-density lipoprotein cholesterol levels were lower compared with healthy women. Serum luteinizing hormone (LH), estradiol (E-2), androstenedione, testosterone and dehydroepiandrosterone sulphate levels were found to be significantly higher in PCOS women compared with healthy women. The levels of E-2, LH and testosterone were positively correlated with leptin levels in PCOS women. Similarly, androstenedione levels and HOMA-IR were positively correlated with homocysteine levels and insulin levels were positively correlated with LH. We conclude that increased homocysteine levels, hyperandrogenaemia, insulin resistance and impaired lipid metabolism contribute to the risk of premature atherosclerosis in PCOS women.en_US
dc.identifier.doi10.1177/147323000803600113
dc.identifier.endpage105en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue1en_US
dc.identifier.pmid18230273
dc.identifier.scopus2-s2.0-39149085035
dc.identifier.scopusqualityQ2
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.1177/147323000803600113
dc.identifier.urihttps://hdl.handle.net/11468/18152
dc.identifier.volume36en_US
dc.identifier.wosWOS:000253171700013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic Ovary-Syndromeen_US
dc.subjectInsulin Resistanceen_US
dc.subjectInsulin-Like Growth Factorsen_US
dc.subjectSex Steroidsen_US
dc.subjectLipid Metabolitesen_US
dc.subjectLeptinen_US
dc.subjectHomocysteineen_US
dc.titleSerum levels of leptin and homocysteine in women with polycystic ovary syndrome and its relationship to endocrine, clinical and metabolic parametersen_US
dc.titleSerum levels of leptin and homocysteine in women with polycystic ovary syndrome and its relationship to endocrine, clinical and metabolic parameters
dc.typeConference Objecten_US

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