Comparison of sVCAM-1 and sICAM-1 levels in maternal serum and vaginal secretion between pregnant women with preterm prelabour ruptures of membranes and healthy pregnant women

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dc.contributor.authorSak, Sibel
dc.contributor.authorBarut, Mert
dc.contributor.authorIncebiyik, Adnan
dc.contributor.authorAgacayak, Elif
dc.contributor.authorKirmit, Adnan
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorSak, Muhammet
dc.date.accessioned2024-04-24T17:07:47Z
dc.date.available2024-04-24T17:07:47Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The study aims to evaluate the maternal serum and the vaginal fluid levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecular (sICAM-1) in pregnant women complicated by preterm prelabour ruptures of membranes (PPROM). Materials and methods: The prospective case control study included 34 pregnant women with PPROM and 34 healthy pregnant women. Patients with additional diseases, a smoking habit and vaginal bleeding, as well as those using antibiotics, during the study period were not included in the study. Cervicovaginal fluid and serum samples were taken during the patients' admission. The demographic data, maternal serum and vaginal fluid sVCAM-1 and sICAM-1, C reactive protein (CRP) and leukocyte counts were noted for all pregnant women included in the study. The sVCAM-1 and sICAM-1 levels were measured by enzyme-linked immunosorbent assay kits. Results: In pregnant women with PPROM, the serum leukocyte (mean +/- SD =11.41 +/- 1.067 versus 9.18 +/- 1.56, p < .0001), serum sVCAM-1 (median 771.20 versus 704.60 ng/ml, p < .001), sICAM-1 (mean +/- SD 213.10 +/- 35.59 ng/ml versus 188.11 +/- 37.35 ng/ml, p = .06), vaginal sVCAM-1 (median 208.00 versus 140.20 ng/ml, p = .014) and sICAM-1 (mean +/- SD 32.32 +/- 6.49 ng/ml versus 24.87 +/- 6.79 ng/ml, p < .001) values were found to be significantly higher in pregnant women with PPROM than in healthy pregnant women. A positive and significant correlation was observed between the leukocyte count and the vaginal sVCAM-1 level (r = 0.850; p < .001). Conclusion: To the best of our knowledge, this is the first study evaluating the levels of sICAM-1 in maternal serum in pregnant women with PPROM. The maternal serum and vaginal fluid sVCAM-1 and sICAM-1 levels can be used as biochemical markers supporting the PPROM diagnosis because of the increase in both maternal serum and vaginal fluid sVCAM-1 and sICAM-1 levels in pregnant women with PPROM.en_US
dc.identifier.doi10.1080/14767058.2017.1395016
dc.identifier.endpage915en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue6en_US
dc.identifier.pmid29096583
dc.identifier.scopus2-s2.0-85032834947
dc.identifier.scopusqualityQ1
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2017.1395016
dc.identifier.urihttps://hdl.handle.net/11468/16990
dc.identifier.volume32en_US
dc.identifier.wosWOS:000454693100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectPpromen_US
dc.subjectSicam-1en_US
dc.subjectSvcam-1en_US
dc.titleComparison of sVCAM-1 and sICAM-1 levels in maternal serum and vaginal secretion between pregnant women with preterm prelabour ruptures of membranes and healthy pregnant womenen_US
dc.titleComparison of sVCAM-1 and sICAM-1 levels in maternal serum and vaginal secretion between pregnant women with preterm prelabour ruptures of membranes and healthy pregnant women
dc.typeArticleen_US

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