Imperforate Hymen with Elevated Serum CA 125 and CA 19-9 Levels

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dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorSak, Sibel
dc.contributor.authorYalinkaya, Ahmet
dc.date.accessioned2024-04-24T17:37:31Z
dc.date.available2024-04-24T17:37:31Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To report the clinical characteristics of 14 patients with imperforate hymen and their levels of tumor markers (CA 19-9 and CA 125). STUDY DESIGN: Fourteen patients with imperforate hymen who followed-up between September 2006 and September 2010 in the Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey, were evaluated retrospectively. The clinical features and the management of the patients are discussed. RESULTS: The mean age of the patients was 13.8 years. All patients had primary amenorrhea and pelvic pain. The most common clinical symptoms were cryptomenorrhea in 14 patients, pelvic pain in 11, palpable abdominal mass in 6, voiding difficulties in 7, and defecation problems in 2. In 6 patients with palpable pelvic mass, the mean +/- standard deviation values of tumor markers were as follows: CA 125, 84.0 +/- 23.7 and CA 19-9, 162 +/- 189. One week after surgery we measured CA 125 and CA 19-9 levels once again. The postoperative mean CA 125 level was 13.8 +/- 3.6, and the mean postoperative CA 19-9 level was 17.5 +/- 3.5. Preoperative leziels of CA 125 and CA 19-9 were significantly higher than those of the postoperative period (p < 0.001 for both comparisons). Six patients were treated by T-shaped incision and 8 patients by a central surgical incision through the hymenal membrane. CONCLUSION: Diagnosis of imperforate hymen is very important before undergoing surgery in a different clinic. Many patients have seen several doctors before receiving a clear diagnosis and have had tumor markers evaluated because the presence of pelvic mass in patients suggests the possibility of a gynecologic malignancy. Imperforate hymen is one of the benign conditions that increase serum CA 125 and CA 19-9 levels and which is not listed in the classical medical textbooks. These markers are not needed for the diagnosis. (J Reprod Med 2013;58:47-50)en_US
dc.identifier.endpage50en_US
dc.identifier.issn0024-7758
dc.identifier.issn1943-3565
dc.identifier.issue1-2en_US
dc.identifier.pmid23447918
dc.identifier.scopus2-s2.0-84873856193
dc.identifier.scopusqualityQ4
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/11468/20992
dc.identifier.volume58en_US
dc.identifier.wosWOS:000314562100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal of Reproductive Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCa 19-9 Antigenen_US
dc.subjectCa 125 Antigenen_US
dc.subjectDiagnosisen_US
dc.subjectHymenen_US
dc.subjectImperforate Hymenen_US
dc.titleImperforate Hymen with Elevated Serum CA 125 and CA 19-9 Levelsen_US
dc.titleImperforate Hymen with Elevated Serum CA 125 and CA 19-9 Levels
dc.typeArticleen_US

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