Prevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpura

Basit Öğe Kaydı
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorOzel, Abdulkadir
dc.contributor.authorOkur, Nilufer
dc.contributor.authorOkur, Nurettin
dc.contributor.authorCil, Timucin
dc.contributor.authorPasa, Semir
dc.contributor.authorAyyildiz, Orhan
dc.date.accessioned2024-04-24T16:02:20Z
dc.date.available2024-04-24T16:02:20Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground To determine the clinical significance of the antinuclear antibody (ANA) test in children and adult patients with idiopathic thrombocytopenic purpura (ITP). Method We conducted a retrospective analysis of 365 children and 108 adult patients with ITP. Patients found to have positive ANA were regularly followed-up by an experienced hematologist until December 2006 for development of symptoms indicative of autoimmune disorder. Mean follow-up 3.6 years (range: 2.1-7 years) for all patients. At the time of diagnosis of ITP, patients with connective tissue diseases (CTD) were excluded. Out of 365 childhood ITP; 301 (82.4%) patients were acute, 64 (17.6%) patients were chronic ITP. ANA titer :1:80 were positive in 33 (9.04%) of 365 patients with childhood ITP; 21 patients (6.9%) were in acute, and 12 patients (18.7%) were in chronic group. Out of 108 adult patients with ITP; 31 (28.7%) patients were acute and 77 (71.3%) patients were chronic ITP cases. ANA titer >= 1:80 were positive in 36 (33.3%) of 108 patients with adult ITP; 12 patients (38.8%) were in acute, and 24 patients (31.2%) were in chronic group. At the end of follow-up period Sjogren's syndrome (SS) was diagnosed in only one adult chronic ITP cases. None of the other ANA positive patients developed SLE or other CTD. Conclusions Our data demonstrated that ANA positivity is often found in adult and children patients with ITP, and indicate that the detection of ANA positivity is not enough to identify those patients with ITP who are at risk of developing SLE or other CTD. There is a statistically significant difference in terms of ANA positivity between childhood acute and chronic ITP patients. We think that ANA positivity may be an indicator in terms of chronicity for childhood ITP. However, large-scale studies should be considered to determine the significance of ANA positivity and their utility in differentiating acute from chronic ITP.en_US
dc.identifier.doi10.1007/s11239-007-0031-y
dc.identifier.endpage168en_US
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.issue2en_US
dc.identifier.pmid17436144
dc.identifier.scopus2-s2.0-38449102378
dc.identifier.scopusqualityQ1
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-007-0031-y
dc.identifier.urihttps://hdl.handle.net/11468/14750
dc.identifier.volume24en_US
dc.identifier.wosWOS:000248794000013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIdiopathic Thrombocytopenic Purpuraen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectAntinuclear Antibodyen_US
dc.subjectConnective Tissue Diseaseen_US
dc.titlePrevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpuraen_US
dc.titlePrevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpura
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu