The effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats

Basit Öğe Kaydı
dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorKuvat, Samet Vasfi
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorYasar, Zeki
dc.contributor.authorGulsun, Niyazi
dc.contributor.authorIlgezdi, Savas
dc.contributor.authorUla, Mahmut
dc.date.accessioned2024-04-24T16:10:56Z
dc.date.available2024-04-24T16:10:56Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractPrevious studies have shown that nicotine increases the risk of necrosis in skin flaps. We investigated the effect of hyperbaric oxygen (HBO2) treatment on the survival of random skin flaps in nicotine-treated rats. Thirty-two SpragueeDawley rats were divided into four groups with eight rats in each group. Group 1 (n=8) was the control, group 2 (n=8) received HBO2 treatment without being exposed to nicotine, group 3 (n=8) received nicotine and group 4 (n=8) received HBO2 treatment with exposure to nicotine. The rats in the nicotine-treated groups were prepared by treating them with nicotine for 28 days. At the end of the 28th day, standard McFarlane-type random skin flaps were lifted from the backs of all the rats. In groups 2 and 4, HBO2 treatment started at the 30th min following the surgery and continued once a day for 7 days. The flap survival rates and histopathological evaluation results related to neovascularisation and granulation tissue formation were significantly better in the HBO2-treated groups (groups 2 and 4) than in the groups that did not receive HBO2 treatment (groups 1 and 3) (p < 0.05). The flap survival rates, neovascularisation and granulation tissue formation were highest in group 2 and lowest in group 3 (p <= 0.001). No significant difference was observed between group 4, which received HBO2 treatment with nicotine exposure, and the control group (group 1) (p > 0.05). In conclusion, our study demonstrates that HBO2 treatment has a positive effect on flap survival in nicotine-treated rats. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bjps.2011.11.015
dc.identifier.endpage493en_US
dc.identifier.issn1748-6815
dc.identifier.issn1878-0539
dc.identifier.issue4en_US
dc.identifier.pmid22137978
dc.identifier.scopus2-s2.0-84857786135
dc.identifier.scopusqualityQ2
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjps.2011.11.015
dc.identifier.urihttps://hdl.handle.net/11468/15194
dc.identifier.volume65en_US
dc.identifier.wosWOS:000301982000023
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Plastic Reconstructive and Aesthetic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNicotineen_US
dc.subjectRaten_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectSkin Flapen_US
dc.titleThe effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated ratsen_US
dc.titleThe effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu