Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder

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dc.contributor.authorDemir, Suleyman
dc.contributor.authorBulut, Mahmut
dc.contributor.authorAtli, Abdullah
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorBez, Yasin
dc.contributor.authorOzdemir, Pinar Guzel
dc.date.accessioned2024-04-24T17:24:33Z
dc.date.available2024-04-24T17:24:33Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. Methods The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. Results Prolidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). Conclusion The findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.en_US
dc.identifier.doi10.4306/pi.2016.13.4.420
dc.identifier.endpage426en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue4en_US
dc.identifier.pmid27482243
dc.identifier.scopus2-s2.0-84982946401
dc.identifier.scopusqualityQ2
dc.identifier.startpage420en_US
dc.identifier.urihttps://doi.org/10.4306/pi.2016.13.4.420
dc.identifier.urihttps://hdl.handle.net/11468/19736
dc.identifier.volume13en_US
dc.identifier.wosWOS:000380733300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPtsden_US
dc.subjectProlidase Activityen_US
dc.subjectNeuroprotectiveen_US
dc.titleDecreased Prolidase Activity in Patients with Posttraumatic Stress Disorderen_US
dc.titleDecreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
dc.typeArticleen_US

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