Hepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkey

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dc.contributor.authorYalcin, K
dc.contributor.authorDegertekin, H
dc.contributor.authorBahcecioglu, IH
dc.contributor.authorDemir, A
dc.contributor.authorAladag, M
dc.contributor.authorYildirim, B
dc.contributor.authorHorasanli, S
dc.date.accessioned2024-04-24T16:10:38Z
dc.date.available2024-04-24T16:10:38Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The clinical relevance of hepatits B virus (HBV) genotypes are poorly understood and it is unclear if the prevalence of HBV genotypes differs with the various clinical features of HBV carriers. The aim of our study was to examine the prevalence of the HBV genotype in a group of patients with chronic hepatitis B, compared to a group with chronic inactive hepatits B surface antigen (HbsAg) carriers. Patients and Methods: HBV genotypes were determined in 32 patients with chronic hepatitis B and in 12 chronic inactive HBsAg carriers. 35 males and nine females with a mean age of 33.95 +/- 13.04 were studied. Serum samples were examined for the presence of HBV DNA by polymerase chain reaction (PIER). Samples negative in first round PCR were further amplified with nested PCR. The PCR product was sequenced with the Cy5/5.5 dye primer kit on a Long Read Tower automated DNA sequencer. Results: HBV DNA was detectable in 29 (66%) and 44 (100%) patients by the PCR with universal primers and nested-PCR, respectively. All patients were found to be infected with HBV genotype D. Genotype D was the only detected type found in different clinical forms of chronic HBV infection, in all hepatitis B e antigen (HbeAg)-positive and negative patients, in at[ patients who had elevated or normal alanine transaminase (ALT) Levels and in all ages. Conclusion: In the present study we could not find any association between genotype D and distinct clinical phenotypes. Genotype D is the predominant type among hepatitis B carriers residing in our region and is not associated with more severe liver diseases. This genotype did not influence clinical manifestations in carriers with chronic hepatitis B virus infection. However, additional Large-scale longitudinal studies are needed to find the relationship of HBV genotypes to liver disease severity and clinical outcomes.en_US
dc.identifier.doi10.1007/s15010-004-3010-7
dc.identifier.endpage29en_US
dc.identifier.issn0300-8126
dc.identifier.issn1439-0973
dc.identifier.issue1en_US
dc.identifier.pmid15007739
dc.identifier.scopus2-s2.0-1142273151
dc.identifier.scopusqualityQ1
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1007/s15010-004-3010-7
dc.identifier.urihttps://hdl.handle.net/11468/14983
dc.identifier.volume32en_US
dc.identifier.wosWOS:000189037700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofInfection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleHepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkeyen_US
dc.titleHepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkey
dc.typeArticleen_US

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