Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study

Basit Öğe Kaydı
dc.contributor.authorErdem, Hakan
dc.contributor.authorSenbayrak, Seniha
dc.contributor.authorMeric, Kaan
dc.contributor.authorBatirel, Ayse
dc.contributor.authorKarahocagil, Mustafa Kasim
dc.contributor.authorHasbun, Rodrigo
dc.contributor.authorSengoz, Gonul
dc.date.accessioned2024-04-24T16:10:38Z
dc.date.available2024-04-24T16:10:38Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective Neuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes. Methods Istanbul-3 study evaluated 263 adult patients with CNS brucellosis from 26 referral centers and reviewed their 242 magnetic resonance imaging (MRI) and 226 computerized tomography (CT) scans of the brain. Results A normal CT or MRI scan was seen in 143 of 263 patients (54.3 %). Abnormal imaging findings were grouped into the following four categories: (a) inflammatory findings: leptomeningeal involvements (44), basal meningeal enhancements (30), cranial nerve involvements (14), spinal nerve roots enhancement (8), brain abscesses (7), granulomas (6), and arachnoiditis (4). (b) White-matter involvement: white-matter involvement (32) with or without demyelinating lesions (7). (c) Vascular involvement: vascular involvement (42) mostly with chronic cerebral ischemic changes (37). (d) Hydrocephalus/cerebral edema: hydrocephalus (20) and brain edema (40). On multivariate logistic regression analysis duration of symptoms since the onset (OR 1.007; 95 % CI 1-28, p = 0.01), polyneuropathy and radiculopathy (OR 5.4; 95 % CI 1.002-1.013, p = 0.044), cerebrospinal fluid (CSF)/serum glucose rate (OR 0.001; 95 % CI 000-0.067, p = 0.001), and CSF protein (OR 2.5; 95 % CI 2.32.7, p = 0.0001) were associated with diffuse inflammation. Conclusions In this study, 45 % of neurobrucellosis patients had abnormal neuroimaging findings. The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses.en_US
dc.identifier.doi10.1007/s15010-016-0901-3
dc.identifier.endpage631en_US
dc.identifier.issn0300-8126
dc.identifier.issn1439-0973
dc.identifier.issue5en_US
dc.identifier.pmid27138335
dc.identifier.scopus2-s2.0-84965053863
dc.identifier.scopusqualityQ1
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1007/s15010-016-0901-3
dc.identifier.urihttps://hdl.handle.net/11468/14985
dc.identifier.volume44en_US
dc.identifier.wosWOS:000388827200008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofInfection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurobrucellosisen_US
dc.subjectComputerized Tomographyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectDiagnosisen_US
dc.subjectInflammationen_US
dc.titleCranial imaging findings in neurobrucellosis: results of Istanbul-3 studyen_US
dc.titleCranial imaging findings in neurobrucellosis: results of Istanbul-3 study
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu