Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study

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dc.authorid0000-0001-7160-1899en_US
dc.authorid0000-0003-1817-1230en_US
dc.authorid0000-0003-3944-1957en_US
dc.contributor.authorDurmaz, Bekir
dc.contributor.authorGüneş, Nedim
dc.contributor.authorKoparal, Mahmut
dc.contributor.authorGül, Mehmet
dc.contributor.authorDündar, Serkan
dc.contributor.authorBingül, Muhammet Bahattin
dc.date.accessioned2024-03-05T11:40:11Z
dc.date.available2024-03-05T11:40:11Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız-Diş-Çene Hastalıkları ve Cerrahisi Bölümüen_US
dc.description.abstractObjective: In this study, it was aimed to histologic and immunohistochemical examined that the effects of quercetin on new bone formation and bone regeneration in critical size rat tibial bone defects. Material & methods: In the study, 56 rats were divided into 4 groups with 14 rats in each group. Control (C) (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and no additional procedure was applied until the end of the experimental setup. Xenograft (X) group (n = 14): Bone defects were created in the tibia bones of the rats and the defects were filled with xenograft. No additional process was applied until the end of the experimental setup. Quercetin (Q) group (n = 14): A defect was created in the tibia bones of the rats and 0.1 mg/kg quercetin was administered by oral gavage until the end of the experimental setup dailly. Quercetin and Xenograft (Q + X) group (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and the defect was filled with xenograft. Until the end of the experimental setup, 0.1 mg/kg quercetin was administered by oral gavage dailly. Rats were sacrificed after 4. and 8 week and tibial bone collected for histomorphometic analysis. Results: It was observed that the parameters related to bone healing were higher in the quercetin administered groups compared to the controls (P < 0,05). Conclusion: Quercetin given by oral gavage may increase bone healing.en_US
dc.identifier.citationDurmaz, B., Güneş, N., Koparal, M., Gül, M., Dündar, S. ve Bingül, M. B. (2023). Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study. Journal of Oral Biology and Craniofacial Research, 13(1), 22-27.en_US
dc.identifier.doi10.1016/j.jobcr.2022.10.008
dc.identifier.endpage27en_US
dc.identifier.issn2212-4268
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85140988494
dc.identifier.scopusqualityQ1
dc.identifier.startpage22en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2212426822001518?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13514
dc.identifier.volume13en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüneş, Nedim
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Oral Biology and Craniofacial Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone defecten_US
dc.subjectBone healingen_US
dc.subjectBone regenerationen_US
dc.subjectNew bone formationen_US
dc.subjectQuercetinen_US
dc.titleInvestigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental studyen_US
dc.titleInvestigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study
dc.typeArticleen_US

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