Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study

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dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorAgacayak, Elif
dc.contributor.authorGoruk, Neval Yaman
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorTogrul, Cihan
dc.date.accessioned2024-04-24T17:18:27Z
dc.date.available2024-04-24T17:18:27Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to investigate the protective effect of honokiol on experimental ischemia/reperfusion injury of rat ovary. Materials and methods: A total of 40 female Wistar albino rats were used in this study. The rats were divided into five groups as follows: sham (Group I), torsion (Group II), torsion + detorsion (Group III), torsion + detorsion + saline (Group IV), and torsion + detorsion + honokiol (Group V). Bilateral adnexa in all the rats except for those in the sham group were exposed to torsion for 3 hours. The rats in Group IV were administered saline, whereas the rats in Group V were administered honokiol by intraperitoneal route 30 minutes before detorsion. Tissue and plasma concentrations of malondialdehyde and nitric oxide were determined. Ovarian tissue was histologically evaluated. Data analyses were performed by means of Kruskal Wallis test and Mann-Whitney U-test (Bonferroni correction) in SPSS 15.0 (Statistical Package for Social Sciences; SPSS Inc., Chicago, IL, USA). Results: The torsion and detorsion groups had higher scores in vascular congestion, hemorrhage, and inflammatory cell infiltration compared with the sham group (P<0.005). In addition, total histopathological scores were significantly higher in the torsion and detorsion groups compared with the sham group (P<0.005). A significant reduction was observed in hemorrhage, inflammatory cell infiltration, and cellular degeneration scores, of all histopathological scores, in the honokiol group (P<0.005). Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and honokiol groups (P<0.005). Ovarian tissue concentrations of nitric oxide, on the other hand, were significantly higher in the torsion group compared with the sham, saline, and honokiol groups (P<0.005). Conclusion: Honokiol has a beneficial effect on ovarian torsion-related ischemia/reperfusion injury.en_US
dc.description.sponsorshipDicle University Scientific Research Commission [13-TF-100]en_US
dc.description.sponsorshipThis research was funded by Dicle University Scientific Research Commission (grant number: 13-TF-100). The authors are grateful to the Department of Obstetrics and Gynecology and Department of Pathology, School of Medicine, Dicle University, for their valuable support.en_US
dc.identifier.doi10.2147/DDDT.S93768
dc.identifier.endpage1083en_US
dc.identifier.issn1177-8881
dc.identifier.pmid27022246
dc.identifier.scopus2-s2.0-84960326309
dc.identifier.scopusqualityQ1
dc.identifier.startpage1077en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S93768
dc.identifier.urihttps://hdl.handle.net/11468/18789
dc.identifier.volume10en_US
dc.identifier.wosWOS:000371533700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvaryen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectHonokiolen_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric Oxideen_US
dc.titleProtective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental studyen_US
dc.titleProtective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study
dc.typeArticleen_US

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