The analysis of immunosuppressant therapy adherence, depression, anxiety, and stress in kidney transplant recipients in the post-transplantation period

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dc.contributor.authorUyar, Betul
dc.date.accessioned2024-04-24T16:18:32Z
dc.date.available2024-04-24T16:18:32Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Our study aimed to analyze the immunosuppressant therapy adherence, anxiety, stress, and depression in kidney transplant recipients in the post-transplantation period. Method: This study was conducted as descriptive and cross-sectional research with the participation of 260 re-cipients who underwent kidney transplantation and were already discharged from the hospital (n = 260). In the data collection process, we used the Personal Information Form, the Immunosuppressant Therapy Adherence Scale (ITAS), and the Depression Anxiety Stress Scale (DASS)-21. The One-Way Analysis of Variance (ANOVA), Chi-Squared test, post hoc and Pearson Correlation analysis methods were used in data analysis. Findings: In our study all participant kidney transplant recipients, 45.4% were age 46-64 years and 81.5% were men. As the recipients' age levels increased, their immunosuppressant therapy adherence levels decreased (p < 0.05). Similarly, kidney recipients with at least 3 adverse events (infection, gastrointestinal problems, edema, blood disorders etc.) had a higher DASS-21 score and a lower ITAS score than those with low side effects. ITAS had a strong negative relationship with DASS-21 (p < 0.05). Recipients' depression, stress, and anxiety scores were, in general, above the medium level. Conclusion: Adherence to the immunosuppressive drug regimen after kidney transplantation and depression, anxiety and stress are in a bidirectional relationship. At the same time, the side effects of immunosuppressive drugs can trigger the development of depression, anxiety and stress. After kidney transplant, recipients are at risk for the development of depression, anxiety, and stress. We recommend early detection of this condition and taking preventive and symptom-reducing interventions.en_US
dc.identifier.doi10.1016/j.trim.2022.101686
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmid35961441
dc.identifier.scopus2-s2.0-85136204395
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.trim.2022.101686
dc.identifier.urihttps://hdl.handle.net/11468/16152
dc.identifier.volume75en_US
dc.identifier.wosWOS:000843877100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTransplant Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnxietyen_US
dc.subjectDepressionen_US
dc.subjectImmunosuppressant Therapyen_US
dc.subjectKidney Transplantationen_US
dc.subjectStressen_US
dc.titleThe analysis of immunosuppressant therapy adherence, depression, anxiety, and stress in kidney transplant recipients in the post-transplantation perioden_US
dc.titleThe analysis of immunosuppressant therapy adherence, depression, anxiety, and stress in kidney transplant recipients in the post-transplantation period
dc.typeArticleen_US

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