Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

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dc.contributor.authorUluca, Unal
dc.contributor.authorEce, Aydin
dc.contributor.authorSen, Velat
dc.contributor.authorKarabel, Duran
dc.contributor.authorYel, Servet
dc.contributor.authorGunes, Ali
dc.contributor.authorTan, Ilhan
dc.date.accessioned2024-04-24T17:40:01Z
dc.date.available2024-04-24T17:40:01Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis risk and neutrophil-tolymphocyte ratio (NLR) as a marker for subclinical inflammation in these patients. In this study, we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients. Material/Methods: The study consisted of 75 FMF patients in attack, 157 attack-free patients, and 77 healthy controls. White blood cell count neutrophil-to-lymphocyte ratio, platelet count, MPV, PDW C-reactive protein levels, and erythrocyte sedimentation rate were recorded. Results: There were no significant differences between attack, attack-free, and control groups in terms of mean MPV and PDW value. NLR value was higher in the attack group. NLR value was similar in attack-free and control groups. Conclusions: We found that MPV and PDW values are similar in FMF patients and healthy controls. NLR was higher in FMF patients in the attack period. Therefore, our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients, and NLR may be an indicator for attack period but not attack-free period.en_US
dc.identifier.endpage1582en_US
dc.identifier.issn1643-3750
dc.identifier.pmid25189760
dc.identifier.scopus2-s2.0-84907210249
dc.identifier.scopusqualityQ1
dc.identifier.startpage1578en_US
dc.identifier.urihttps://hdl.handle.net/11468/21524
dc.identifier.volume20en_US
dc.identifier.wosWOS:000341749000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectInflammationen_US
dc.subjectMean Platelet Volumeen_US
dc.titleUsefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Feveren_US
dc.titleUsefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever
dc.typeArticleen_US

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