NMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisone

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dc.authorid0000-0002-4238-5012en_US
dc.contributor.authorZhumakova, Symbat
dc.contributor.authorTen, Assel
dc.contributor.authorZharkynbek, Tolganay
dc.contributor.authorYu, Valentina
dc.contributor.authorSeilkhanov, Tulegen
dc.contributor.authorBasharimova, Anna
dc.contributor.authorBayazit, Sarah
dc.contributor.authorAydemir, Murat
dc.contributor.authorZazybin, Alexey
dc.date.accessioned2022-03-04T10:45:18Z
dc.date.available2022-03-04T10:45:18Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.descriptionWOS:000752960600001
dc.description.abstractForming complexes with beta-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical ingredient. In this study, the inclusion behavior between beta-cyclodextrin (beta-CD) and diphenhydramine, clonidine, and tolperisone in DMSO-d(6) was investigated using NMR spectroscopy. H-1, C-13, COSY, HMQC, and ROESY data were applied to determine the structure of inclusion complexes, and molecular docking analysis was engaged to identify the most favorable host-guest interactions in the inclusion complexes. Complexation of beta-CD with diphenhydramine, clonidine, and tolperisone is accompanied by the insertion of a molecular fragment of the guest molecule, one molecule of diphenhydramine and tolperisone, and two molecules of clonidine, into the inner sphere of one host molecule. The reported study provides useful information for the potential application of the complexation of beta-CD with diphenhy-dramine, clonidine, and tolperisone. This may be a good strategy for the development of solid pharmaceutical dosage forms based on beta-CDs as a drug delivery system.en_US
dc.identifier.citationZhumakova, S., Ten, A., Zharkynbek, T., Yu, V., Seilkhanov, T., Basharimova, A. ve başkaları. (2022). NMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisone. SN Applied Sciences, 4(3), 1-9.en_US
dc.identifier.doi10.1007/s42452-022-04958-5en_US
dc.identifier.endpage9en_US
dc.identifier.issn2523-3963
dc.identifier.issn2523-3971
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85124482862en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s42452-022-04958-5
dc.identifier.urihttps://hdl.handle.net/11468/9319
dc.identifier.volume4en_US
dc.identifier.wosWOS:000752960600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAydemir, Murat
dc.language.isoenen_US
dc.publisherSpringer International Publishing AGen_US
dc.relation.ispartofSN Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiphenhydramineen_US
dc.subjectClonidineen_US
dc.subjectTolperisoneen_US
dc.subjectBeta-Cyclodextrinen_US
dc.subjectInclusion complexesen_US
dc.subjectNMR Spectroscopyen_US
dc.titleNMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisoneen_US
dc.typeArticleen_US

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