NMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisone

Yükleniyor...
Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer International Publishing AG

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Forming complexes with beta-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical ingredient. In this study, the inclusion behavior between beta-cyclodextrin (beta-CD) and diphenhydramine, clonidine, and tolperisone in DMSO-d(6) was investigated using NMR spectroscopy. H-1, C-13, COSY, HMQC, and ROESY data were applied to determine the structure of inclusion complexes, and molecular docking analysis was engaged to identify the most favorable host-guest interactions in the inclusion complexes. Complexation of beta-CD with diphenhydramine, clonidine, and tolperisone is accompanied by the insertion of a molecular fragment of the guest molecule, one molecule of diphenhydramine and tolperisone, and two molecules of clonidine, into the inner sphere of one host molecule. The reported study provides useful information for the potential application of the complexation of beta-CD with diphenhy-dramine, clonidine, and tolperisone. This may be a good strategy for the development of solid pharmaceutical dosage forms based on beta-CDs as a drug delivery system.

Açıklama

WOS:000752960600001

Anahtar Kelimeler

Diphenhydramine, Clonidine, Tolperisone, Beta-Cyclodextrin, Inclusion complexes, NMR Spectroscopy

Kaynak

SN Applied Sciences

WoS Q DeÄŸeri

N/A

Scopus Q DeÄŸeri

Q2

Cilt

4

Sayı

3

Künye

Zhumakova, S., Ten, A., Zharkynbek, T., Yu, V., Seilkhanov, T., Basharimova, A. ve başkaları. (2022). NMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisone. SN Applied Sciences, 4(3), 1-9.