Malign Transformation in the Low Grade Astrocytomas and Related Factors

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dc.contributor.authorKamasak, Kaan
dc.contributor.authorEkici, Mehmet Ali
dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorTucer, Bulent
dc.contributor.authorBasarslan, Seyit Kaan
dc.contributor.authorKurtsoy, Ali
dc.date.accessioned2024-04-24T17:24:58Z
dc.date.available2024-04-24T17:24:58Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: Retrospective investigation of prognostic factors in low-grade astrocytomas. MATERIAL and METHODS: In the study, prognostic factors were prospectively identified and assumed to be effective on prognosis, which were reviewed in 67 cases diagnosed as low-grade astrocytoma with craniotomy between May 1998 to December 2005 at Erciyes University Neurosurgery Department. Assessment of demographic, neurologic, radiological, surgical and clinical features of cases and adjuvant therapies and their relationship with prognosis were evaluated. Post-operative cumulative survival of the cases was estimated by using the Kaplan-Meier method. The Log Rank test was used to compare the survival curve of the sub-groups. Multivariate analysis of survival was analyzed by using the Cox regression method. RESULTS: It was seen that malign transformation occurred in 9 patients of subtotal resection group. The difference was statistically significant (p < 0.01). malign transformation was detected in one female (3.2%) and 8 male patients (22.2%). Difference in favor of men was statistically significant (p < 0.05). Malignant transformation was detected in 7 of the patients given post-operative radiotherapy, only 2 patients displayed malign transformation in the group which received no radiotherapy. Comparison of groups revealed a significant difference (p=0.01). CONCLUSION: Detection of higher malign transformation rate in cases underwent radiotherapy than those did not and the statistical significance in this meaning mandates to revise treatment plan regarding radiotherapy.en_US
dc.identifier.doi10.5137/1019-5149.JTN.5347-11.3
dc.identifier.endpage575en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid23015332en_US
dc.identifier.startpage566en_US
dc.identifier.trdizinid150774en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.5347-11.3
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/150774
dc.identifier.urihttps://hdl.handle.net/11468/19893
dc.identifier.volume22en_US
dc.identifier.wosWOS:000310118600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLow-Grade Astrocytomaen_US
dc.subjectPrognostic Factorsen_US
dc.subjectMalign Transformationen_US
dc.subjectRadiotherapyen_US
dc.titleMalign Transformation in the Low Grade Astrocytomas and Related Factorsen_US
dc.typeArticleen_US

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