Relationship between thyroid function and carotid artery plaque ulceration

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dc.contributor.authorSevuk, Utkan
dc.contributor.authorBahadir, Mehmet Veysi
dc.contributor.authorAltindag, Rojhat
dc.contributor.authorBaysal, Erkan
dc.contributor.authorAltintas, Bernas
dc.contributor.authorYaylak, Baris
dc.contributor.authorAdiyaman, Mehmet Sahin
dc.date.accessioned2024-04-24T16:10:38Z
dc.date.available2024-04-24T16:10:38Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractCarotid artery plaque ulceration (PU) is known to be associated with cerebrovascular events (CVE). Even within euthyroid ranges, thyroid function has been reported to be associated with carotid atherosclerosis. However, the relationship between thyroid function and carotid PU remains unclear. Our aim was to determine the relationship between thyroid function and PU in patients with internal carotid artery stenosis (ICS). Records of patients with CVE were retrospectively reviewed. A total of 250 consecutive patients with ICS who had computed tomography angiography (CTA) of the carotid arteries following hospitalization were included in the study. CTA was used for the evaluation of carotid artery plaque morphology and ulceration. Plaque morphology was classified as fatty, mixed or calcified. Patients were divided into two groups according to the presence or absence of PU. Subclinical hypothyroidism (SCH) and hypothyroidism were significantly more common in patients with PU (p < 0.001 and p = 0.003, respectively). Patients with PU had higher incidence of low-normal FT4 levels (p = 0.02). Compared with patients who had no PU, patients with PU had decreased FT4 levels and elevated TSH levels (p = 0.001 and p = 0.001, respectively). TSH level (OR 1.33, p = 0.001), SCH (OR 4.2, p = 0.001), hypothyroidism (OR 3.15, p = 0.037), fatty plaque (OR 2.16, p = 0.01) and calcified plaque (OR 0.19, p < 0.001) were independently associated with PU. Our results suggest that SCH and hypothyroidism could be a risk factor for PU and subsequent CVE. Thyroid functions may be useful for risk stratification of patients with ICS.en_US
dc.identifier.doi10.1007/s13760-015-0435-y
dc.identifier.endpage587en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue4en_US
dc.identifier.pmid25672265
dc.identifier.scopus2-s2.0-84947496117
dc.identifier.scopusqualityQ2
dc.identifier.startpage581en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-015-0435-y
dc.identifier.urihttps://hdl.handle.net/11468/14979
dc.identifier.volume115en_US
dc.identifier.wosWOS:000365265800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid Artery Stenosisen_US
dc.subjectPlaque Ulcerationen_US
dc.subjectThyroid Functionen_US
dc.subjectFt4en_US
dc.subjectTshen_US
dc.titleRelationship between thyroid function and carotid artery plaque ulcerationen_US
dc.titleRelationship between thyroid function and carotid artery plaque ulceration
dc.typeArticleen_US

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