Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats

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dc.contributor.authorTumer, Cemil
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorDiken, Huda
dc.contributor.authorTasdemir, Ezel
dc.contributor.authorSermet, Abdurrahman
dc.date.accessioned2024-04-24T16:18:18Z
dc.date.available2024-04-24T16:18:18Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractGhrelin, an endogenous ligand for growth hormone secretagogue receptor, was identified in the rat stomach. This peptide acts through nitric oxide (NO) by expressing endothelial nitric oxide synthase (eNOS) and down regulating inducible nitric oxide synthase (NOS) at its gastroproprotective effect against restraint stress induced damage. Recently the glirelin receptor has also been detected in peripheral systems including immune tissue. We have investigated the possible effect of glirelin on phagocytic activity of peritoneal macrophages in acute coldrestraint stress (ACRS) exposed rats. The rats were divided into control, stress and ghrelin groups. In ghrelin groups, single dose and three days consecutive dose of ghrelin (20 mu g/kg. i.p.) were applied to rats that were exposed to ACRS for 4 h. I rut of saline was injected i.p. after ACRS for 3 consecutive days to the rats of the stress groups. Ghrelin administration reduced the increased phagocytic activity induced by ACRS. We conclude that ghrelin exerts an important role at macrophage phagocytic activity in ACRS exposed rats. (c) 2006 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.regpep.2006.08.010
dc.identifier.endpage117en_US
dc.identifier.issn0167-0115
dc.identifier.issn1873-1686
dc.identifier.issue2-3en_US
dc.identifier.pmid17112606
dc.identifier.scopus2-s2.0-33845965718
dc.identifier.scopusqualityN/A
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2006.08.010
dc.identifier.urihttps://hdl.handle.net/11468/15984
dc.identifier.volume138en_US
dc.identifier.wosWOS:000244012400010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofRegulatory Peptides
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectInducible Nitric Oxide Synthaseen_US
dc.subjectAcute Cold-Restraint Stressen_US
dc.subjectPhagocytic Activityen_US
dc.titleEffect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed ratsen_US
dc.titleEffect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats
dc.typeArticleen_US

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