No Effect of Antidepressant Treatment on Elevated Serum Ceruloplasmin Level in Patients with First-Episode Depression: A Longitidunal Study

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dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorBez, Yasin
dc.contributor.authorSelek, Salih
dc.contributor.authorKarababa, Ibrahim Fatih
dc.contributor.authorBulut, Mahmut
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorCelik, Hakim
dc.date.accessioned2024-04-24T16:10:53Z
dc.date.available2024-04-24T16:10:53Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Aims. Ceruloplasmin, an acute phase reactant with antioxidant capacity, has been found to be increased in some psychiatric disorders like schizophrenia and obsessive compulsive disorder. However, studies in depression are very scarce. We under-took this study determine the serum ceruloplasmin levels of depressive patients before and after treatment, to compare them with those of healthy control subjects, and to assess any possible association of ceruloplasmin and treatment response. Methods. Nineteen (8 male, 11 female) patients with major depressive disorder and 40 (17 male, 23 female) healthy control subjects were included in the study. The patients received naturalistic antidepressant treatment for 8 weeks after diagnosis. Serum ceruloplasmin levels and Hamilton Depression Rating Scale (HAM-D) scores of the patients were measured before and after their antidepressant treatment. Blood collection for ceruloplasmin measurement was done only once for healthy control subjects. Results. Patients' ceruloplasmin levels before and after antidepressant treatment were significantly higher than control subjects (t = 7.569, p < 0.001 and t = 6.764, p < 0.001, respectively). Despite clinical improvement, ceruloplasmin did not show any significant change after treatment in patients with depression (t = -1.163, p = 0.260) and remained higher than levels of control subjects. No correlation was found between HAM-D score, presence of response, and ceruloplasmin levels. Conclusions. Compared to healthy control subjects, ceruloplasmin level seemed to be higher in patients with depression and remained high, despite acute antidepressant treatment. Improvement in clinical measurements of depression after antidepressant treatment was not reflected as significant alterations in serum ceruloplasmin levels. (C) 2012 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2012.05.006
dc.identifier.endpage297en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue4en_US
dc.identifier.pmid22704847en_US
dc.identifier.scopus2-s2.0-84864091530en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2012.05.006
dc.identifier.urihttps://hdl.handle.net/11468/15167
dc.identifier.volume43en_US
dc.identifier.wosWOS:000307603500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectDepressionen_US
dc.subjectOxidative Stressen_US
dc.subjectCeruloplasminen_US
dc.subjectAntidepressant Treatmenten_US
dc.titleNo Effect of Antidepressant Treatment on Elevated Serum Ceruloplasmin Level in Patients with First-Episode Depression: A Longitidunal Studyen_US
dc.typeArticleen_US

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