Risk Factors for Colistin-Associated Acute Kidney Injury: A Multicenter Study from Turkey

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dc.contributor.authorGul, Serdar
dc.contributor.authorKuscu, Ferit
dc.contributor.authorAydemir, Hande
dc.contributor.authorOzturk, Dogan Baris
dc.contributor.authorDeveci, Ozcan
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorKacmaz, Birgul
dc.date.accessioned2024-04-24T17:33:08Z
dc.date.available2024-04-24T17:33:08Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the incidence of acute kidney injury (AKI) and risk factors due to colistin use in patients infected with multidrug-resistant pathogens. This multicenter, retrospective, observational study was conducted in Turkey, at 5 different research and university hospitals. Cox regression analyses were performed, to determine independent predictors of AKI. From April 2012 to July 2014, a total of 216 patients aged between 18-94 years, treated with colistimethate sodium (CMS) were included in the study. The mean age of the patients was 60.3 +/- 20.1 years. The overall incidence of AKI was 34.3% (74/216) at any time during treatment. Concomitant use of loop diuretics, baseline creatinine level, and CMS dosage were independently associated with AKI. According to our results, patients with higher baseline creatinine levels, or patients who had to use concomitant loop diuretics may need to be monitored more closely, and dose adjustment should be done promptly. More comprehensive studies are, however, still needed to evaluate the efficacy of low-dose colistin since higher doses tend to increase the risk of AKI.en_US
dc.identifier.doi10.7883/yoken.JJID.2014.501
dc.identifier.endpage112en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue2en_US
dc.identifier.pmid26166495
dc.identifier.scopus2-s2.0-84961612932
dc.identifier.scopusqualityQ2
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.7883/yoken.JJID.2014.501
dc.identifier.urihttps://hdl.handle.net/11468/20451
dc.identifier.volume69en_US
dc.identifier.wosWOS:000373245600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleRisk Factors for Colistin-Associated Acute Kidney Injury: A Multicenter Study from Turkeyen_US
dc.titleRisk Factors for Colistin-Associated Acute Kidney Injury: A Multicenter Study from Turkey
dc.typeArticleen_US

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