Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation

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dc.authorid0000-0003-1748-7620en_US
dc.authorid0000-0002-5438-8560en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-4074-5168en_US
dc.authorid0000-0003-3958-1028en_US
dc.authorid0000-0001-6098-3908en_US
dc.contributor.authorBakaç, Mehmet Salih
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAltındağ, Fikret
dc.contributor.authorDönmez, Fatih
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorDoğan, Abdulahad
dc.date.accessioned2023-12-01T10:10:40Z
dc.date.available2023-12-01T10:10:40Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBackgrounds: Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. (SP) is used in folk medicine for the treatment of diabetes. The aim of the study was to determine the phenolic profile of SP extract (SPE) by LC-MS/MS and to investigate the antidiabetic, hepatoprotective and nephroprotective effects of SPE in streptozotosin (STZ)-induced diabetic rat model. Methods: Forty-two rats were randomly divided into six groups (n = 7): Control (nondiabetic), diabetes mellitus (DM), DM + SP-100 (diabetic rats treated with SPE, 100 mg/kg/day), DM + SP-200 (diabetic rats treated with SPE, 200 mg/kg/day), DM + SP-400 (diabetic rats treated with SPE, 400 mg/kg/day) and DM + Gly-3 (diabetic rats treated with glibenclamide, 3 mg/kg/day). Live body weight, fasting blood glucose (FBG) level, antidiabetic, serum biochemical and lipid profile parameters, antioxidant defense system, malondyaldehyde (MDA) and histopathological examinations in liver, kidney and pancreas were evaluated. Results: Apigenin, luteolin, quinic acid, cosmosiin and epigallocatechin were determined to be the major phenolic compounds in the SPE. Administration of the highest dose of SP extract (400 mg/kg) resulted in a significant reduction in FBG levels and glycosylated hemoglobin levels in STZ-induced diabetic rats, indicating an antihyperglycemic effect. SPE (200 and 400 mg/kg) and glibenclamide significantly improved MDA in liver and kidney tissues. In addition, SPE contributed to the struggle against STZ-induced oxidative stress by stimulating antioxidant defense systems. STZ induction negatively affected liver, kidney and pancreas tissues according to histopathological findings. Treatment with 400 mg/kg and glibenclamide attenuated these negative effects. Conclusions: In conclusion, the extract of the aerial part of Scutellaria pinnatifida subsp. pichleri has hepatoprotective, nephroprotective and insulin secretion stimulating effects against STZ-induced diabetes and its complications due to its antidiabetic and antioxidant phytochemicals such as apigenin, luteolin, quinic acid, cosmosiin and epigallocatechin.en_US
dc.identifier.citationBakaç, M. S., Doğan, A., Yılmaz, M. A., Altındağ, F., Dönmez, F. ve Battal, A. (2023). Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation. BMC Complementary Medicine and Therapies, 23(1), 1-15.en_US
dc.identifier.doi10.1186/s12906-023-04252-w
dc.identifier.endpage15en_US
dc.identifier.issn2662-7671
dc.identifier.issue1en_US
dc.identifier.pmid37964249
dc.identifier.scopus2-s2.0-85176943180
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-023-04252-w
dc.identifier.urihttps://hdl.handle.net/11468/13071
dc.identifier.volume23en_US
dc.identifier.wosWOS:001105017000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.relation.ispartofBMC Complementary Medicine and Therapies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectApigeninen_US
dc.subjectDiabetesen_US
dc.subjectPhenolic contenten_US
dc.subjectScutellaria Pinnatifida subsp. pichlerien_US
dc.titleAmeliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluationen_US
dc.titleAmeliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation
dc.typeArticleen_US

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