Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis

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dc.contributor.authorUcak, Haydar
dc.contributor.authorDemir, Betul
dc.contributor.authorCicek, Demet
dc.contributor.authorDertlioglu, Selma Bakar
dc.contributor.authorAkkurt, Zeynep Meltem
dc.contributor.authorUcmak, Derya
dc.contributor.authorHalisdemir, Nurhan
dc.date.accessioned2024-04-24T17:20:30Z
dc.date.available2024-04-24T17:20:30Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.en_US
dc.identifier.doi10.3109/09546634.2013.800181
dc.identifier.endpage457en_US
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue6en_US
dc.identifier.pmid23638997
dc.identifier.scopus2-s2.0-84887860147
dc.identifier.scopusqualityQ1
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.3109/09546634.2013.800181
dc.identifier.urihttps://hdl.handle.net/11468/19092
dc.identifier.volume24en_US
dc.identifier.wosWOS:000327257900013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Dermatological Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnal Itchingen_US
dc.subjectDermatology Life Quality Indexen_US
dc.subjectEczema Area And Severity Indexen_US
dc.subjectAtopic Dermatitisen_US
dc.subjectPruritus Anien_US
dc.subjectTacrolimus Ointmenten_US
dc.titleEfficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitisen_US
dc.titleEfficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis
dc.typeArticleen_US

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