Protective effect of Diyarbakir watermelon juice on carbon tetrachloride-induced toxicity in rats

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dc.contributor.authorAltas, Sevcan
dc.contributor.authorKizil, Goksel
dc.contributor.authorKizil, Murat
dc.contributor.authorKetani, Aydin
dc.contributor.authorHaris, Parvez I.
dc.date.accessioned2024-04-24T16:11:30Z
dc.date.available2024-04-24T16:11:30Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was designed to evaluate the effect of Diyarbakir watermelon (Citrullus lanatus cv. Surme) juice on lipid peroxidation states in rat liver, kidney and brain. In vivo administration of carbon tetrachloride (CCl4) once a week for 28 days caused a significant elevation of serum markers of liver damage, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB) and decrease in albumin when compared to the control group. However, administration of carbon tetrachloride along with watermelon juice or ursodeoxycolic acid (UDCA) significantly reduces these changes. Increased lipid peroxide (LPO) level was observed in the liver, kidney and brain tissues after CCl4 administration. However, watermelon juice and UDCA treatment prevented the increase in LPO. The results indicated that watermelon juice protects the liver, kidney and brain tissues from experimental CCl4 toxicity in rats and that the protective effect of watermelon juice may be due to its antioxidant activity and inhibition of lipid peroxide formation. In conclusion, present study reveals biological evidence that supports the use of watermelon juice in the treatment of chemical-induced hepatotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.fct.2011.06.064
dc.identifier.endpage2438en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue9en_US
dc.identifier.pmid21740951
dc.identifier.scopus2-s2.0-79960845755
dc.identifier.scopusqualityQ1
dc.identifier.startpage2433en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2011.06.064
dc.identifier.urihttps://hdl.handle.net/11468/15413
dc.identifier.volume49en_US
dc.identifier.wosWOS:000295188600072
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWatermelon Juiceen_US
dc.subjectHepatotoxicityen_US
dc.subjectUrsodeoxycolic Aciden_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidanten_US
dc.titleProtective effect of Diyarbakir watermelon juice on carbon tetrachloride-induced toxicity in ratsen_US
dc.titleProtective effect of Diyarbakir watermelon juice on carbon tetrachloride-induced toxicity in rats
dc.typeArticleen_US

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