Value of tenascin-C content and association with clinicopathological parameters in uterine cervical lesions

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dc.contributor.authorBüyükbayram, Hüseyin
dc.contributor.authorArslan, Adem
dc.contributor.orcid0000-0002-7168-1507
dc.date.accessioned2024-04-24T15:59:24Z
dc.date.available2024-04-24T15:59:24Z
dc.date.issued2002
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Blim Dalıen_US
dc.description.abstractTo determine whether the content of the matrix protein tenascin-C (Tn-C) is of diagnostic or prognostic value in cervical lesions, we evaluated increases in Tn-C immunoreactivity in 80 formalin-fixed, paraffin-em bedded biopsies and surgical specimens of the uterine cervix. Tn-C content in the basement membrane zone and in the stroma was graded and compared to some prognostic parameters. In the normal cervix, Tn-C formed a thin continuous band. In cervicitis, Tn-C bands thickened in the basement membrane zone and the adjacent stroma in the form of thin filaments. In 30 squamous intraepithelial lesions (SILs) of various grades, Tn-C bands were either slightly (I +) or moderately (2 +) thickened in the basement membrane zone, while slight stromal Tn-C immunoreactivity in the form of thin bands was observed in 12 cases, regardless of grade and inflammatory stromal reaction. In invasive carcinoma, Tn-C content was markedly increased in the stroma and around the invasive nests of tumors. The intensity of Tn-C immunoreactivity was significantly higher in grade I tumors than in others (p < 0.04). The intensity of increase in Tn-C immunoreactivity was 10.5-fold (95% CI 3.39-32.5) higher in invasive cervical carcinomas than in others (cervicitis, low-grade SIL and high-grade SIL) (p = 0.0001). A significant correlation was found between weak Tn-C immunoreactivity and lymphatic space invasion (p = 0.001), lymph node metastasis (p = 0.01), desmoplastic stromal component (p = 0.0001) and stromal inflammation (p = 0.002). In conclusion, increase in Tn-C immunoreactivity may be of value in the assessment of non-invasive and invasive cervical lesions and the appearance of Tn-C may be an indicator of adequate biologic defense in cervical cancer patients. (C) 2002 Wiley-Liss, Inc.en_US
dc.identifier.citationBüyükbayram, H. ve Arslan, A. (2002). Value of tenascin-C content and association with clinicopathological parameters in uterine cervical lesions. International Journal of Cancer, 100(6), 719-722.
dc.identifier.doi10.1002/ijc.10546
dc.identifier.endpage722en_US
dc.identifier.issn0020-7136
dc.identifier.issue6en_US
dc.identifier.pmid12209613
dc.identifier.scopus2-s2.0-0037143802
dc.identifier.scopusqualityQ1
dc.identifier.startpage719en_US
dc.identifier.urihttps://doi.org/10.1002/ijc.10546
dc.identifier.urihttps://hdl.handle.net/11468/14047
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/ijc.10546
dc.identifier.volume100en_US
dc.identifier.wosWOS:000177211900016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBüyükbayram, Hüseyin
dc.institutionauthorArslan, Adem
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofInternational Journal of Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTenascin-Cen_US
dc.subjectUterine cervixen_US
dc.subjectClinicopathologic parametersen_US
dc.subjectGradeen_US
dc.subjectPrognosisen_US
dc.titleValue of tenascin-C content and association with clinicopathological parameters in uterine cervical lesionsen_US
dc.titleValue of tenascin-C content and association with clinicopathological parameters in uterine cervical lesions
dc.typeArticleen_US

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