Causative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study

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dc.contributor.authorHatipoglu, Mustafa
dc.contributor.authorMutluoglu, Mesut
dc.contributor.authorTurhan, Vedat
dc.contributor.authorUzun, Gunalp
dc.contributor.authorLipsky, Benjamin A.
dc.contributor.authorSevim, Erol
dc.contributor.authorDemiraslan, Hayati
dc.date.accessioned2024-04-24T16:15:03Z
dc.date.available2024-04-24T16:15:03Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. Methods: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). Results: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. Conclusions: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2016.02.013
dc.identifier.endpage916en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue5en_US
dc.identifier.pmid26965794
dc.identifier.scopus2-s2.0-84959521823
dc.identifier.scopusqualityQ2
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2016.02.013
dc.identifier.urihttps://hdl.handle.net/11468/15621
dc.identifier.volume30en_US
dc.identifier.wosWOS:000378759700027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiotic Therapyen_US
dc.subjectDiabetic Footen_US
dc.subjectGuidelineen_US
dc.subjectInfectionen_US
dc.subjectTurkeyen_US
dc.titleCausative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center studyen_US
dc.titleCausative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study
dc.typeArticleen_US

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