Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model

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dc.authorid0000-0002-8299-1789en_US
dc.authorid0000-0002-3280-1430en_US
dc.contributor.authorErcan, Serdar
dc.contributor.authorAktaş, Ayfer
dc.contributor.authorKemaloğlu, Mustafa Serdar
dc.date.accessioned2022-07-01T07:41:01Z
dc.date.available2022-07-01T07:41:01Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.descriptionWOS:000632229500016
dc.descriptionPMID: 33746123
dc.description.abstractBACKGROUND: Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. METHODS: 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. RESULTS AND DISCUSSION: Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. CONCLUSION: Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation.en_US
dc.identifier.citationErcan, S., Aktaş, A. ve Kemaloğlu, M.S. (2021). Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model. Annali Italiani di Chirurgia, 92(1), 98-102.en_US
dc.identifier.endpage102en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1en_US
dc.identifier.pmid33746123
dc.identifier.scopusScopusIdYok
dc.identifier.scopusqualityQ3
dc.identifier.startpage98en_US
dc.identifier.urihttps://hdl.handle.net/11468/10084
dc.identifier.volume92en_US
dc.identifier.wosWOS:000632229500016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErcan, Serdar
dc.institutionauthorAktaş, Ayfer
dc.institutionauthorKemaloğlu, Mustafa Serdar
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani di Chirurgia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-lipoic aciden_US
dc.subjectMethyl-prednisoloneen_US
dc.subjectOxygen radicalsen_US
dc.subjectSpinal cord injuryen_US
dc.titleAntioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat modelen_US
dc.titleAntioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model
dc.typeArticleen_US

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