Are maternal and fetal parameters related to perinatal mortality in HELLP syndrome?

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dc.contributor.authorGuzel, Ali Irfan
dc.contributor.authorKuyumcuoglu, Umur
dc.contributor.authorCelik, Yusuf
dc.date.accessioned2024-04-24T16:00:17Z
dc.date.available2024-04-24T16:00:17Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe designed this retrospective study to evaluate the association between maternal and fetal parameters and perinatal mortality in hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. In this retrospective study, 152 pregnancies complicated with HELLP syndrome were evaluated. Risk factors recorded were maternal age, gravidity, gestational age (weeks), systolic and diastolic blood pressure, platelet count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), fetal weight, and Apgar scores. The association of these factors with perinatal mortality was determined. Statistical analyses were performed using the Chi-square (chi (2)) test with Yates' correction, the Student's t test, logarithmic transformation, and the logistic regression method. Ninety-two (60.52%) patients had mild preeclampsia, 46 (22.2%) had eclampsia, and 14 (15.2%) had severe preeclampsia. The fetal mortality rate was higher in eclamptic and severe preeclamptic patients (P = 0.029). No correlation was found between maternal age, laboratory values (platelet count, ALT, AST, and LDH), or systolic and diastolic blood pressure and fetal morbidity. According to the logistic regression model, fetuses with prematurity, low birth weight, and low Apgar scores (Apgar score 1 a parts per thousand currency sign 3 and Apgar score 5 a parts per thousand currency sign 5) were found to be at significant risk for perinatal mortality (P < 0.001). The odds ratios (95% CI) were 3.0 (2-5), 3.42 (1.82-6.41), 0.62 (0.44-0.86) and 4.66 (2.04-10.63), respectively. Maternal laboratory and clinical parameters were not associated with fetal mortality. Fetal prematurity, low birth weight, and low Apgar scores were significantly associated with fetal mortality. The HELLP syndrome and severe preeclampsia may be life threatening to the mother; therefore, the accepted treatment is expeditious delivery. Our study indicates that prevention of prematurity must be the main priority for the fetus in pregnancies complicated by the HELLP syndrome. This can be efficaciously achieved using glucocorticoid therapy for lung maturity and ensuring that delivery is at an experienced hospital with a multidisciplinary approach including a neonatal intensive care unit.en_US
dc.identifier.doi10.1007/s00404-010-1534-x
dc.identifier.endpage1232en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue6en_US
dc.identifier.pmid20526778
dc.identifier.scopus2-s2.0-79956080083
dc.identifier.scopusqualityQ2
dc.identifier.startpage1227en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-010-1534-x
dc.identifier.urihttps://hdl.handle.net/11468/14430
dc.identifier.volume283en_US
dc.identifier.wosWOS:000290536100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellp Syndromeen_US
dc.subjectPerinatalen_US
dc.subjectMortalityen_US
dc.subjectRisk Factorsen_US
dc.titleAre maternal and fetal parameters related to perinatal mortality in HELLP syndrome?en_US
dc.titleAre maternal and fetal parameters related to perinatal mortality in HELLP syndrome?
dc.typeArticleen_US

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