Green synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract

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dc.authorid0000-0003-1756-9757en_US
dc.authorid0000-0001-8133-6670en_US
dc.authorid0000-0002-2317-0489en_US
dc.authorid0000-0002-1487-1953en_US
dc.authorid0000-0003-3758-0654en_US
dc.contributor.authorİpek, Polat
dc.contributor.authorBaran, Mehmet Fırat
dc.contributor.authorBaran, Ayşe
dc.contributor.authorHatipoğlu, Abdulkerim
dc.contributor.authorKeskin, Cumali
dc.contributor.authorYıldıztekin, Mahmut
dc.date.accessioned2023-10-09T13:25:38Z
dc.date.available2023-10-09T13:25:38Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractGold nanoparticles (Au NPs) have potentially therapeutic properties as they are synthesized via biomolecules as reducing and stabilizing agent(s). The aim of this study is to develop an easy and eco-friendly method for the synthesis of Au NPs using extracts from the Allium cepa (AC) red peel (skin) extract and investigate the antibacterial and antioxidant activity and also inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. UV–Vis peak at ~ 564 nm confirmed the Au NPs absorbance. TEM images revealed the formation of Au NPs with mostly spherical shapes and sizes between 6.08 and 54.20 nm. FTIR analysis confirmed the important biological compounds responsible for the reduction of gold. The strong absorption property of Au NPs was studied by EDX. The produced Au NPs demonstrated significant antibacterial and antifungal activity against the bacterial and fungal strains tested, as well as efficient inhibitory activity against both AChE and BChE enzymes. The highest antimicrobial activities were found against Staphylococcus aureus (0.06° mg/ml) and Candida albicans (0.06° mg/ml). The antioxidant test findings revealed that AC-Au NPs had lesser activity when compared to normal antioxidants. The Au NPs showed excellent inhibitory efficacy against AChE and BChE. The proposed green technique could encourage the innocuous generation of Au NPs, implying therapeutic possibilities.en_US
dc.identifier.citationPolat, İ., Baran, M. F., Baran, A., Hatipoğlu, A. Keskin, C. ve Yıldıztekin, M. (2023). Green synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract. Biomass Conversion and Biorefinery, Article in Press.en_US
dc.identifier.doi10.1007/s13399-023-04362-y
dc.identifier.endpage10en_US
dc.identifier.issn2190-6815
dc.identifier.scopus2-s2.0-85160849619
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s13399-023-04362-y
dc.identifier.urihttps://hdl.handle.net/11468/12781
dc.identifier.volumeArticle in Pressen_US
dc.identifier.wosWOS:001000323000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİpek, Polat
dc.language.isoenen_US
dc.publisherSpringer Science and Business Mediaen_US
dc.relation.ispartofBiomass Conversion and Biorefinery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllium cepaen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectAntioxidanten_US
dc.subjectGold nanoparticlesen_US
dc.subjectPlant-based nanoparticlesen_US
dc.titleGreen synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extracten_US
dc.titleGreen synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract
dc.typeArticleen_US

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