Effects of antioxidant agents against cyclosporine-induced hepatotoxicity

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dc.contributor.authorAkbulut, Sami
dc.contributor.authorElbe, Hulya
dc.contributor.authorEris, Cengiz
dc.contributor.authorDogan, Zumrut
dc.contributor.authorToprak, Gulten
dc.contributor.authorYalcin, Erhan
dc.contributor.authorOtan, Emrah
dc.date.accessioned2024-04-24T16:15:22Z
dc.date.available2024-04-24T16:15:22Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: To investigate the potential protective antioxidant role of ursodeoxycholic acid (UDCA), melatonin, and allopurinol treatment in cyclosporine (CsA)-induced hepatotoxicity. Methods: Hepatotoxicity was established in Sprague-Dawley rats by daily administration of CsA. Treatment groups were additionally administered UDCA, melatonin, or allopurinol treatments. Rats that received no CsA and no treatments served as a control group. Liver samples from each group were examined by histopathologic analysis to determine the effects of CsA treatment on liver morphology. Biochemical assays were also used to determine the effect of CsA treatment on liver function, in the presence or absence of UDCA, melatonin, or allopurinol. Results: CsA treatment induced hepatotoxicity, resulting in sinusoidal dilatation, congestion, infiltration, hydropic degeneration, and loss of glycogen storage in the liver. From a molecular perspective, the CsA treatment increased levels of malondialdehyde (MDA) levels, decreased levels of reduced glutathione and xanthine oxidase, and decreased activities of superoxide dismutase and catalase. The CsA treatment also resulted in decreased serum total antioxidant capacity, whereas alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin levels, and total oxidant status were increased. Treatment with UDCA, melatonin, or allopurinol reduced the CsA-induced histopathologic changes, as compared with CsA-treated samples. In addition, UDCA, melatonin, or allopurinol treatment mitigated the CsA-induced effects on glutathione and MDA levels, and on superoxide dismutase and catalase activities, as well as reduced the CsA-mediated perturbations in serum levels of total antioxidant capacity, total oxidant status, and alkaline phosphatase. Conclusions: UDCA, allopurinol, and melatonin may each help to protect against CsA-induced damage to liver tissues, possibly through effects on the antioxidant system. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2014.08.042
dc.identifier.endpage666en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid25281288
dc.identifier.scopus2-s2.0-84917675908
dc.identifier.scopusqualityQ1
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2014.08.042
dc.identifier.urihttps://hdl.handle.net/11468/15775
dc.identifier.volume193en_US
dc.identifier.wosWOS:000346244300021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclosporineen_US
dc.subjectHepatotoxicityen_US
dc.subjectAntioxidant Agentsen_US
dc.subjectUrsodeoxycholic Aciden_US
dc.subjectMelatoninen_US
dc.subjectAllopurinolen_US
dc.titleEffects of antioxidant agents against cyclosporine-induced hepatotoxicityen_US
dc.titleEffects of antioxidant agents against cyclosporine-induced hepatotoxicity
dc.typeArticleen_US

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