Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes to migraine susceptibility in Turkish population

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dc.contributor.authorCoskun, Salih
dc.contributor.authorYucel, Yavuz
dc.contributor.authorCim, Abdullah
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorVarol, Sefer
dc.contributor.authorOzdemir, Hasan H.
dc.date.accessioned2024-04-24T17:33:25Z
dc.date.available2024-04-24T17:33:25Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractMigraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease, Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study was to evaluate genetic variants in genes involved in oestrogen receptor and oestrogen hormone metabolism in a Turkish population. A total of 12 SNPs in the ESR1, ESR2. FSHR, CYP19A1 SHBG and NRIP1 genes were genotyped in 142 migraine cases and 141 nonmigraine controls, using a 13iolVtark 96,96 dynamic array system. In addition, gene gene interactions were analysed using generalized multifactor dimensionality reduction (GMDR) methods. According to GI\ADR analysis, our results indicated that there was a significant association between migraine and gene gene interaction a.mong the CYP19A1 FSHR, ESR1 and NRIP1, Single-gene variant analysis showed that a significant association was observed between the TT genotype of rs10046 and migraine susceptibility. When the analysis was performed only in women, the GG genotype of rs222974I was different between migaineurs and controls. When the female migraine patients were divided into two groups, migraine related to menstruation ilVIRM) or migraine not related to menstruation (MN RN), OG genotype of rs726281 was significantly associated with M FM. These results suggested that rs10046 could play a potential role in migyaine susceptibility in Turkish population, Also, the rare GG genotype of rs726281 appears to influence migraine susceptibility in a recessive manner in MRM subgroup of female patients. In addition, variant GG genotype of rs2229741 may reduce the risk of migraine in Turkish women.en_US
dc.description.sponsorshipDicle University Scientific Research Projects (DUBAP) [10-TF-150]en_US
dc.description.sponsorshipThis research is supported by Dicle University Scientific Research Projects (DUBAP), project no: 10-TF-150.en_US
dc.identifier.endpage140en_US
dc.identifier.issn0022-1333
dc.identifier.issn0973-7731
dc.identifier.issue1en_US
dc.identifier.pmid27019440
dc.identifier.scopus2-s2.0-84960434689
dc.identifier.scopusqualityQ3
dc.identifier.startpage131en_US
dc.identifier.urihttps://hdl.handle.net/11468/20676
dc.identifier.volume95en_US
dc.identifier.wosWOS:000372660600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIndian Acad Sciencesen_US
dc.relation.ispartofJournal of Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectMenstruation-Related Migraineen_US
dc.subjectEsr1en_US
dc.subjectCy19a1en_US
dc.subjectNrip1en_US
dc.subjectFshren_US
dc.titleContribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes to migraine susceptibility in Turkish populationen_US
dc.titleContribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes to migraine susceptibility in Turkish population
dc.typeArticleen_US

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