Neutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-Schonlein purpura

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dc.contributor.authorEce, Aydin
dc.contributor.authorKelekci, Selvi
dc.contributor.authorHekimoglu, Askin
dc.contributor.authorKocamaz, Halil
dc.contributor.authorBalik, Hasan
dc.contributor.authorYolbas, Ilyas
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-04-24T16:01:55Z
dc.date.available2024-04-24T16:01:55Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the role of neutrophil activation, protein oxidation and ceruloplasmin (CLP) in the pathogenesis of Henoch-Schonlein purpura (HSP), which has not been investigated previously. Serum activities of myeloperoxidase (MPO) and arylesterase (ARYL) and levels of free thiol groups, CLP and total oxidant status (TOS) were measured in 29 children with HSP at the onset of the disease and during remission in comparison with 30 healthy subjects. Patients at active stage had significantly higher MPO activity (391 +/- 277 vs. 155 +/- 154 U/l, P<0.001), higher CLP (832 +/- 120 vs. 682 +/- 114 mg/dl, P<0.001) and TOS values (20.7 +/- 11.8 vs. 7.5 +/- 2.8 mu mol H2O2/l, P<0.001) than the controls, respectively. Patients had significantly lower ARYL activity (158x10(3) +/- 3x10(3) vs. 187x10(3) +/- 4 46x10(3) U/l, P<0.001) and lower free thiol levels (234 +/- 48 vs. 279 +/- 26 mu mol/l, P<0.001) than the controls, respectively. Significantly positive correlations were found between TOS and MPO (r=0.437, P=0.018) and TOS and CLP (r=0.409, P=0.028) at disease onset, whereas a negative correlation was found between MPO and thiol (r=-0.597, P=0.001) during remission. In conclusion, protein oxidation and neutrophil activation may play important roles in the pathogenesis of HSP. Further research is required to understand the potential linkage between oxidant stress and complications and to develop therapeutic strategies in HSP.en_US
dc.identifier.doi10.1007/s00467-007-0475-5
dc.identifier.endpage1157en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue8en_US
dc.identifier.pmid17404760en_US
dc.identifier.scopus2-s2.0-34548426149en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1151en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-007-0475-5
dc.identifier.urihttps://hdl.handle.net/11468/14486
dc.identifier.volume22en_US
dc.identifier.wosWOS:000247310400009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHenoch-Schonlein Purpuraen_US
dc.subjectOxidative Stressen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectCeruloplasminen_US
dc.subjectArylesteraseen_US
dc.subjectProtein Oxidationen_US
dc.titleNeutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-Schonlein purpuraen_US
dc.typeArticleen_US

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