Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia

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dc.contributor.authorBayhan, GH
dc.contributor.authorKoçyigit, Y
dc.contributor.authorAtamer, A
dc.contributor.authorAtamer, Y
dc.contributor.authorAkkus, Z
dc.date.accessioned2024-04-24T16:24:44Z
dc.date.available2024-04-24T16:24:44Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims. To evaluate changes in lipid profile, serum levels of malondialdehyde (MDA) and lipoprotein(a) (Lp(a)) and placental MDA in preeclamptic women, and to evaluate the atherogenic role of these changes in the pathophysiology of preeclampsia. Method. A cross-sectional study was performed in 20 normal pregnant women, 25 women with mild preeclampsia and 28 women with severe preeclampsia in the third trimester. MDA, which is the endproduct of lipid peroxidation, was measured in placental tissue by the thiobarbituric acid (TBA) method of Ohkawa and colleagues and in serum by the TBA method of Asakawa and Matsushita. Serum lipid levels were measured by with an autoanalyzer, serum apolipoprotein (Apo) A-I and Apo B were measured by nephelometric assay and serum Lp(a) level using a nephelometric agglutination assay method. In preeclamptic and normal pregnant women, multiple comparisons between groups were performed by one-way analysis of variance supplemented with Tukey's HSD post hoc test. The association between placental and serum concentrations among groups was analyzed using the Pearson correlation test. Results. Serum levels of MDA, Lp(a), total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and placental MDA were significantly higher, and high-density lipoprotein cholesterol (HDL-C) and Apo A-I levels were significantly lower, in severely preeclamptic and mildly preeclamptic women than in the normal pregnant women, but no difference was observed in Apo B among groups. Serum level of Lp(a) was positively correlated with body mass index in severely preeclamptic women (r = 0.489:, p = 0.008). A significant positive correlation was also found between serum level of MDA and systolic blood pressure in women with severe preeclampsia (r = 0.375, p = 0.049). Conclusions. Our findings suggest that high Lp(a), lipid peroxidation, LDL-C and TG, and low HDL-C and Apo A-I levels, are important risk factors for atherosclerosis among preeclamptic women.en_US
dc.identifier.doi10.1080/09513590500097382
dc.identifier.endpage6en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue1en_US
dc.identifier.pmid16048794
dc.identifier.scopus2-s2.0-23244461834
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/09513590500097382
dc.identifier.urihttps://hdl.handle.net/11468/16832
dc.identifier.volume21en_US
dc.identifier.wosWOS:000231098100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectLipoprotein(A)en_US
dc.subjectLipoproteinsen_US
dc.subjectLipid Peroxidationen_US
dc.titlePotential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsiaen_US
dc.titlePotential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia
dc.typeArticleen_US

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