Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis

Basit Öğe Kaydı
dc.contributor.authorSevuk, Utkan
dc.contributor.authorBahadir, Mehmet Veysi
dc.contributor.authorAltindag, Rojhat
dc.contributor.authorBaysal, Erkan
dc.contributor.authorYaylak, Baris
dc.contributor.authorAy, Nurettin
dc.contributor.authorAyaz, Firat
dc.date.accessioned2024-04-24T17:18:29Z
dc.date.available2024-04-24T17:18:29Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: To date, no validated biomarkers with high sensitivity and specificity have been established for diagnosis of pulmonary embolism (PE) in patients with deep venous thrombosis (DVT). There is a need to develop simple and reliable noninvasive tests that can accurately identify patients with PE, even in small hospitals or clinics. The aim of this study was to investigate the value of mean platelet volume (MPV) and platelet distribution width (PDW) for predicting occurrence of PE in patients with DVT. Methods: Records of acute DVT patients were reviewed retrospectively. Group 1 consisted of 50 patients with acute DVT and group 2 consisted of 50 patients with acute DVT who developed PE during follow-up. The control group consisted of patients with uncomplicated primary varicose veins of the lower limbs. Venous peripheral blood samples for measurement of MPV, PDW, and platelet count were drawn on admission, before the treatment, and at the time of PE diagnosis. Results: MPV and PDW levels at the time of PE diagnosis were higher in group 2 than group 1 (P<0.001 and P=0.026, respectively). Receiver operating characteristics analysis revealed that a 5.2% increase in admission PDW during follow-up provided 70% sensitivity and 82% specificity (area under the curve, 0.80), and a 6.6% increase in admission MPV during follow-up provided 74% sensitivity and 83% specificity (area under the curve, 0.84) for prediction of PE occurrence in patients with DVT. PDW and MPV levels at the time of PE diagnosis were found to be independent risk factors for the occurrence of PE in patients with DVT. Conclusion: Serial measurements of MPV and PDW, and percent change in MPV and PDW appears to be a useful marker for predicting occurrence of acute PE in patients with a first episode of acute proximal DVT.en_US
dc.identifier.doi10.2147/TCRM.S89355
dc.identifier.endpage1249en_US
dc.identifier.issn1178-203X
dc.identifier.pmid26316769
dc.identifier.scopus2-s2.0-84940112121
dc.identifier.scopusqualityQ1
dc.identifier.startpage1243en_US
dc.identifier.urihttps://doi.org/10.2147/TCRM.S89355
dc.identifier.urihttps://hdl.handle.net/11468/18801
dc.identifier.volume11en_US
dc.identifier.wosWOS:000360061700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofTherapeutics and Clinical Risk Management
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeep Venous Thrombosisen_US
dc.subjectPulmonary Embolismen_US
dc.subjectPlatelet Indicesen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPlatelet Distribution Widthen_US
dc.titleValue of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosisen_US
dc.titleValue of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu