The protective effects of captopril and nitric oxide on solitary kidney after chronic partial ureteric obstruction

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dc.contributor.authorÖztürk, H
dc.contributor.authorDokucu, AI
dc.contributor.authorOtçu, S
dc.contributor.authorGezici, A
dc.contributor.authorKetani, A
dc.contributor.authorYildiz, FR
dc.contributor.authorÖzdemir, E
dc.date.accessioned2024-04-24T16:24:06Z
dc.date.available2024-04-24T16:24:06Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective To determine whether vasodilator agents (captopril and nitric oxide) change the morphological and functional effects of chronic partial ureteric obstruction in solitary kidney tissue in unilaterally nephrectomized rats, Materials and methods Each of 50 prepubertal Wistar albino rats underwent right nephrectomy and were then assigned to one of five groups. Rats in group 1 underwent a sham operation (control) and in the other groups the ureter of the remaining kidney was partially obstructed by surgery. In group 2, no drug treatments were given; in groups 3, 4 and 5 captopril, L-arginine methyl ester (L-Arg) or NG-nitro-L-arginine-methyl ester, respectively, were given for 3 weeks, In all rats, diuretic scintigraphy was used to measure kidney perfusion, glomerular filtration rate (GFR) and concentration. Blood urea nitrogen (BUN), serum creatinine levels, kidney parenchymal weight and pelvic volume were measured and the kidneys evaluated histopathologically. Results Renal perfusion was significantly greater in both group 3 and 4 than in group 2, The GFR was 18% greater in group 3 and 22.3% greater in group 4 than in group 2. The GFR was decreased by 67% in group 5 compared with the control group, The mean parenchymal weight, mean pelvic volume, BUN and serum creatinine in the four groups with a partially obstructed ureter were significantly different from the control group. There also were significant differences between group 2 and groups 3-5, and between group 2 and group 3. Histological damage was severe in all four groups with partial ureteric obstruction, but in the drug-treated groups, medullary fibrosis was less frequent. Conclusion After 3 weeks of treatment, captopril and L-Arg both improved kidney perfusion, GFR, BUN and serum creatinine levels, but were less effective in preventing parenchymal atrophy and changes in pelvic volume.en_US
dc.identifier.doi10.1046/j.1464-410x.2001.02247.x
dc.identifier.endpage99en_US
dc.identifier.issn1464-4096
dc.identifier.issue1en_US
dc.identifier.pmid11446855
dc.identifier.scopus2-s2.0-0035732995
dc.identifier.scopusqualityQ1
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1046/j.1464-410x.2001.02247.x
dc.identifier.urihttps://hdl.handle.net/11468/16494
dc.identifier.volume88en_US
dc.identifier.wosWOS:000169891900021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofBju International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive Hydronephrosisen_US
dc.subjectRatsen_US
dc.subjectCaptoprilen_US
dc.subjectNitric Oxideen_US
dc.subjectL-Arginine Methyl Esteren_US
dc.subjectNg-Nitro-L-Arginine-Methyl Esteren_US
dc.titleThe protective effects of captopril and nitric oxide on solitary kidney after chronic partial ureteric obstructionen_US
dc.titleThe protective effects of captopril and nitric oxide on solitary kidney after chronic partial ureteric obstruction
dc.typeArticleen_US

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