Oxidative Damage is Ameliorated by Curcumin Treatment in Brain and Sciatic Nerve of Diabetic Rats

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dc.contributor.authorAcar, Abdullah
dc.contributor.authorAkil, Esref
dc.contributor.authorAlp, Harun
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorKibrisli, Erkan
dc.contributor.authorInal, Ali
dc.contributor.authorUnan, Fatma
dc.date.accessioned2024-04-24T17:20:25Z
dc.date.available2024-04-24T17:20:25Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo date, there have not been enough studies about the effects of curcumin against oxidative stress on sciatic nerves caused by streptozotocin (STZ) in diabetic rats. Therefore, this study was undertaken to determine whether curcumin, by virtue of its antioxidant properties, could affect the oxidant/antioxidant balance in the sciatic nerve and brain tissues of streptozotocin (STZ)-induced diabetic rats. A total of 28 rats were randomly divided into four groups of seven rats each: normal controls, only curcumin treated, diabetic controls, and diabetics treated with curcumin. Biomarkers-malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and NO levels-for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. We found a significant increase in MDA, NO, TOS, and OSI, along with a reduction in TAS levels in the brains and sciatic nerves of the STZ-induced diabetic rats (for both parameters p < 0.05). The MDA, TOS, OSI, and NO levels in these tissues were significantly reduced in the curcumin-treated diabetic group compared to the untreated diabetic group. In conclusion, the results of this study suggested that curcumin exhibits neuroprotective effects against oxidative damage in the brain and sciatic tissues of diabetic rats.en_US
dc.identifier.doi10.3109/00207454.2012.657380
dc.identifier.endpage372en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue7en_US
dc.identifier.pmid22248035
dc.identifier.scopus2-s2.0-84862178247
dc.identifier.scopusqualityQ2
dc.identifier.startpage367en_US
dc.identifier.urihttps://doi.org/10.3109/00207454.2012.657380
dc.identifier.urihttps://hdl.handle.net/11468/19036
dc.identifier.volume122en_US
dc.identifier.wosWOS:000305011800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCurcuminen_US
dc.subjectDiabeticen_US
dc.subjectOxidative Stressen_US
dc.subjectSciatic Nerveen_US
dc.titleOxidative Damage is Ameliorated by Curcumin Treatment in Brain and Sciatic Nerve of Diabetic Ratsen_US
dc.titleOxidative Damage is Ameliorated by Curcumin Treatment in Brain and Sciatic Nerve of Diabetic Rats
dc.typeArticleen_US

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