How to Increase the Diagnostic Value of Malignancy-related Ascites: Discriminative Ability of the Ascitic Tumour Markers

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dc.contributor.authorTuzun, Y.
dc.contributor.authorYilmaz, M.
dc.contributor.authorDursun, M.
dc.contributor.authorCanoruc, F.
dc.contributor.authorCelik, Y.
dc.contributor.authorCil, T.
dc.contributor.authorBoyraz, T.
dc.date.accessioned2024-04-24T17:14:43Z
dc.date.available2024-04-24T17:14:43Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractMaking a differential diagnosis between malignant and non-malignant ascites is an important clinical issue, but cytological examination has a relatively low diagnostic sensitivity. This study aimed to find a discriminative model that distinguished between malignancy-related and non-malignant ascites. The study included 107 patients: 50 with nonmalignant and 57 with malignant ascites. Ascites was analysed using a range of tumour markers and standard cytology. Standardized canonical discriminant function coefficients were used to distinguish between ascites types. The combination of carbohydrate antigen (CA) 15-3, carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA-21.1) discriminated between malignancy-related ascites and non-malignant ascites with an accuracy of 98.8% compared with an accuracy of 77.8% for cytological examination. In conclusion, the use of a discriminant function constructed from a combination of CA15-3, CEA and CYFRA-21.1 could distinguish malignant from non-malignant ascites with greater accuracy than cytological examination. Further studies in larger population groups are warranted.en_US
dc.identifier.doi10.1177/147323000903700110
dc.identifier.endpage95en_US
dc.identifier.issn0300-0605
dc.identifier.issue1en_US
dc.identifier.pmid19215677
dc.identifier.scopus2-s2.0-64149098878
dc.identifier.scopusqualityQ2
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1177/147323000903700110
dc.identifier.urihttps://hdl.handle.net/11468/18156
dc.identifier.volume37en_US
dc.identifier.wosWOS:000264163500010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectCancer Patientsen_US
dc.subjectDiagnosisen_US
dc.subjectRumour Markersen_US
dc.subjectAscitesen_US
dc.subjectDiscriminant Functionen_US
dc.titleHow to Increase the Diagnostic Value of Malignancy-related Ascites: Discriminative Ability of the Ascitic Tumour Markersen_US
dc.titleHow to Increase the Diagnostic Value of Malignancy-related Ascites: Discriminative Ability of the Ascitic Tumour Markers
dc.typeArticleen_US

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