The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia

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dc.authorid0000-0002-4337-9327en_US
dc.contributor.authorDancik, Garrett M.
dc.contributor.authorVarışli, Lokman
dc.contributor.authorVlahopoulos, Spiros A.
dc.date.accessioned2023-05-30T13:15:45Z
dc.date.available2023-05-30T13:15:45Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractThe protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members. The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to neutralize lipid peroxidation products and to generate retinoic acid; however, only ALDH1A1 emerges as a significant risk factor in acute myeloid leukemia. Not only is the gene ALDH1A1 on average significantly overexpressed in the poor prognosis group at the RNA level, but its protein product, ALDH1A1 protects acute myeloid leukemia cells from lipid peroxidation byproducts. This capacity to protect cells can be ascribed to the stability of the enzyme under conditions of oxidant stress. The capacity to protect cells is evident both in vitro, as well as in mouse xenografts of those cells, shielding cells effectively from a number of potent antineoplastic agents. However, the role of ALDH1A1 in acute myeloid leukemia has been unclear in the past due to evidence that normal cells often have higher aldehyde dehydrogenase activity than leukemic cells. This being true, ALDH1A1 RNA expression is significantly associated with poor prognosis. It is hence imperative that ALDH1A1 is methodically targeted, particularly for the acute myeloid leukemia patients of the poor prognosis risk group that overexpress ALDH1A1 RNA.en_US
dc.identifier.citationDancik, G.M., Varişli, L. ve Vlahopoulos, S.A. (2023). The Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia. International Journal of Molecular Sciences, 24(11), 9372.en_US
dc.identifier.doi10.3390/ijms24119372
dc.identifier.issue11en_US
dc.identifier.pmid37298333
dc.identifier.scopus2-s2.0-85161662202
dc.identifier.scopusqualityQ1
dc.identifier.startpage9372en_US
dc.identifier.urihttps://www.mdpi.com/1422-0067/24/11/9372
dc.identifier.urihttps://hdl.handle.net/11468/11934
dc.identifier.volume24en_US
dc.identifier.wosWOS:001005742800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVarışli, Lokman
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute myeloid leukemiaen_US
dc.subjectALDH1A1en_US
dc.subject4-hydroxy-2-nonenalen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidant stressen_US
dc.titleThe Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemiaen_US
dc.titleThe Molecular context of oxidant stress response in cancer establishes ALDH1A1 as a critical target: What this means for acute myeloid leukemia
dc.typeArticleen_US

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