Angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis

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dc.contributor.authorTaşdemir, Nebahat
dc.contributor.authorEce, Aydın
dc.contributor.authorTekeş, Selahattin
dc.contributor.authorDikici, Süber
dc.contributor.authorGüneş, Ali
dc.contributor.authorBalık, Hasan
dc.contributor.orcid0000-0001-6764-8336
dc.date.accessioned2024-04-24T15:59:18Z
dc.date.available2024-04-24T15:59:18Z
dc.date.issued2006
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractSubacute sclerosing panencephalitis (SSPE) is a progressive, debilitating, and fatal brain disorder caused by mutant measles virus infection. Although both viral and host factors seem to be involved in SSPE, the exact pathogenesis remains to be determined. Autoimmune demyelination is characteristic of SSPE. The blood angiotensin-converting enzyme (ACE) activity and angiotensin II (Ang II) levels are associated with the ACE gene polymorphism. Proinflammatory effects of Ang II may contribute to the development of SSPE. The aim of this study was to investigate whether the ACE and Ang II type I receptor (AT1R) (A1166C) gene polymorphisms were associated with SSPE. The polymorphisms were investigated by polymerase chain reaction (PCR) in 43 patients with SSPE and 100 healthy controls. The genotype distribution of the SSPE children and healthy controls were as follows: DD 58.1% versus 34.0, ID 37.2% versus 48.0%, and II 4.7% versus 18.0, respectively (P=0.012). Allele frequencies of patients and controls were D 76.7% versus 58.0%, and I 23.3% versus 42.0%, respectively (P = 0.004). The frequency of DD genotype and D allele were significantly higher in SSPE children compared with controls (P < 0.05). AT1R, gene polymorphism distribution was found to be similar in SSPE children and control subjects: AA 55.8% versus 60.7%, AC 37.2% versus 32.1%, and CC 7.0% versus 7.2%, respectively (P > 0.05). In conclusion, the results of this study suggest that the DD genotype of ACE I/D polymorphism maybe related to SSPE. Due to small size of this study, further studies with more patients are needed to confirm these results. (c) 2006 Wiley-Liss, Inc.en_US
dc.identifier.citationTaşdemir, N., Ece, A., Tekeş, S., Dikici, S., Güneş, A. ve Balık, H. (2006). Angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 141(5), 445-448.
dc.identifier.doi10.1002/ajmg.b.30343
dc.identifier.endpage448en_US
dc.identifier.issn1552-4841
dc.identifier.issn1552-485X
dc.identifier.issue5en_US
dc.identifier.pmid16741935
dc.identifier.scopus2-s2.0-33745788188
dc.identifier.scopusqualityQ2
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1002/ajmg.b.30343
dc.identifier.urihttps://hdl.handle.net/11468/13952
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.b.30343
dc.identifier.volume141Ben_US
dc.identifier.wosWOS:000238622300003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaşdemir, Nebahat
dc.institutionauthorEce, Aydın
dc.institutionauthorTekeş, Selahattin
dc.institutionauthorGüneş, Ali
dc.institutionauthorBalık, Hasan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAceen_US
dc.subjectAt1ren_US
dc.subjectGene polymorphismen_US
dc.subjectPathogenesisen_US
dc.subjectSspeen_US
dc.titleAngiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitisen_US
dc.titleAngiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis
dc.typeArticleen_US

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