Guided bone regeneration with local zoledronic acid and titanium barrier: An experimental study

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dc.contributor.authorDundar, Serkan
dc.contributor.authorOzgur, Cem
dc.contributor.authorYaman, Ferhan
dc.contributor.authorCakmak, Omer
dc.contributor.authorSaybak, Arif
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorAlan, Hilal
dc.date.accessioned2024-04-24T17:21:00Z
dc.date.available2024-04-24T17:21:00Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effects on new bone formation of autogenous blood alone or in combination with zoledronic acid (ZA), a -tricalcium phosphate (-TCP) graft or ZA plus a -TCP graft placed under titanium barriers. For this purpose, eight adult male New Zealand white rabbits were used in the study, each with four titanium barriers fixed around four sets of nine holes drilled in the calvarial bones. The study included four groups, each containing 2 rabbits. In the autogenous blood (AB group), only autogeneous blood was placed under the titanium barriers. The three experimental groups were the AB+ZA group, with autogenous blood plus ZA, the AB+-TCP group, with autogeneous blood plus a -TCP graft, and the AB+-TCP+ZA group, with autogeneous blood plus a -TCP graft and ZA mixture under the titanium barriers. The animals were sacrificed after 3 months. The amounts of new bone formation identified histomorphometrically were found to be higher after 3 months than at the time of surgery in all groups. The differences between the groups were examined with histomorphometric analysis, and statistically significant differences were identified at the end of the 3 months. The bone formation rate in the AB+-TCP+ZA group was determined to be significantly higher than that in the other groups (P<0.05). In the AB+ZA and AB+-TCP groups, the bone formation rate was determined to be significantly higher than that in the AB group (P<0.05). No statistically significant difference in bone formation rate was observed between the AB+-TCP and AB+ZA groups. Local ZA used with autogeneous blood and/or graft material appears to be a more effective method than the use of autogeneous blood or graft alone in bone augmentation executed with a titanium barrier.en_US
dc.identifier.doi10.3892/etm.2016.3598
dc.identifier.endpage2020en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue4en_US
dc.identifier.pmid27698687
dc.identifier.scopus2-s2.0-84988014336
dc.identifier.scopusqualityN/A
dc.identifier.startpage2015en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2016.3598
dc.identifier.urihttps://hdl.handle.net/11468/19333
dc.identifier.volume12en_US
dc.identifier.wosWOS:000385578200010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGuided Bone Regenerationen_US
dc.subjectZoledronic Aciden_US
dc.subjectTitanium Barrieren_US
dc.subjectRabbit Calvariumen_US
dc.titleGuided bone regeneration with local zoledronic acid and titanium barrier: An experimental studyen_US
dc.titleGuided bone regeneration with local zoledronic acid and titanium barrier: An experimental study
dc.typeArticleen_US

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