The effects of exogenous interleukin-4 on hypoxia-induced lung injury

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dc.contributor.authorOzturk, H
dc.contributor.authorOzturk, H
dc.contributor.authorBuyukbayram, H
dc.contributor.authorTuncer, MC
dc.date.accessioned2024-04-24T16:00:11Z
dc.date.available2024-04-24T16:00:11Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of recombinant human interleukin-4 (rhIL-4) on hypoxia-induced lung injury in immature rats. The study was performed on 1-day-old Sprague Dawley rat pups. Group 1 (n=7) served as nonhypoxic controls. Group 2 (untreated, n=7) rats were subjected to hypoxia-reoxygenation (H/O) and were then returned to their mothers. Group 3 (rhIL-4 treated, n=7) rats were subjected to H/O, were returned to their mothers, and were treated with rhIL-4 (75 mu g/kg subcutaneously) for the next 3 days. All animals were killed on day 4 and lung specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histological changes. In the untreated group, MDA levels were significantly increased compared to control and rhIL-4 groups. In the rhIL-4 treated group, MDA levels were not significantly different compared to control group. The rhIL-4 treated group had a significantly lower score of pathological lesions and alveolar hemorrhage grade values than the untreated group. The untreated animals had areas marked intraalveolar hemorrhage, capillary congestion, interstitial edema, and hypercellularity of lung that were not seen in the rhIL-4 treated rats. In conclusion, this study found beneficial effects of rhIL-4 in an experimental model on the hypoxia-induced lung injury.en_US
dc.identifier.doi10.1007/s00383-006-1635-6
dc.identifier.endpage201en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue2en_US
dc.identifier.pmid16425061
dc.identifier.scopus2-s2.0-31944440491
dc.identifier.scopusqualityQ2
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-006-1635-6
dc.identifier.urihttps://hdl.handle.net/11468/14398
dc.identifier.volume22en_US
dc.identifier.wosWOS:000235058700016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLungen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectCytokineen_US
dc.subjectInterleukin-4en_US
dc.titleThe effects of exogenous interleukin-4 on hypoxia-induced lung injuryen_US
dc.titleThe effects of exogenous interleukin-4 on hypoxia-induced lung injury
dc.typeArticleen_US

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