Effects of specific inhibition of cyclooxygenease-2 on kidney in bilateral adrenalectomized rats

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dc.contributor.authorOzturk, Hulya
dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorGedik, Senol
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorKetani, Aydin
dc.date.accessioned2024-04-24T16:02:24Z
dc.date.available2024-04-24T16:02:24Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the kidney, prostaglandins represent important physiological modulators of renal hemodynamics and salt and water homeostasis. In this experimental study of bilaterally adrenalectomized (ADX) rats, we aimed to investigate whether the administration of selective (celecoxib) inhibitor of COX-2 would alter the morphological and functional changes in rat kidney tissue. Twenty-one male Sprague-Dawley rats weighing 225-250 g were used. The animals were divided into three groups. Group 1 rats (Sham-control, n = 7) did not receive any treatment. In group 2 rats (ADX/Untreated, n = 7), bilateral ADX was performed via a single dorsal incision. In group 3 (ADX/COX-2) rats, the same operation was performed as described for group 2 and then the COX-2 inhibitor celecoxib was administered by gavage for a period of 7 days. On the 7th day of the study, renal function was assessed by measurements of blood urea nitrogen (BUN) and serum creatinine levels. Biopsies were obtained from the remaining left kidneys before killing the rats. There was no significant difference in the BUN and creatinine values between the groups. In ADX/Untreated group, capillary congestion in glomerule, inflammation, hemorrhage and congestion in intertubular area, and cytoplasmic vacuolation in renal tubules was observed. Mild damage was observed in the ADX/COX-2 group. The number of macrophages was significantly decreased in ADX/COX-2 group when compared to ADX/Untreated group (P < 0.0001). Our study indicates that celecoxib may be an important factor affecting renal morphological changes after the bilaterally ADX.en_US
dc.identifier.doi10.1007/s11255-006-0074-6
dc.identifier.endpage270en_US
dc.identifier.issn0301-1623
dc.identifier.issue1en_US
dc.identifier.pmid17268902
dc.identifier.scopus2-s2.0-34248228259
dc.identifier.scopusqualityQ2
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-006-0074-6
dc.identifier.urihttps://hdl.handle.net/11468/14776
dc.identifier.volume39en_US
dc.identifier.wosWOS:000246203900050
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclooxygenaseen_US
dc.subjectCelecoxiben_US
dc.subjectKidneyen_US
dc.subjectAdrenalectomyen_US
dc.subjectRaten_US
dc.titleEffects of specific inhibition of cyclooxygenease-2 on kidney in bilateral adrenalectomized ratsen_US
dc.titleEffects of specific inhibition of cyclooxygenease-2 on kidney in bilateral adrenalectomized rats
dc.typeArticleen_US

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