A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots

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dc.contributor.authorYilmaz, Serif
dc.contributor.authorBayan, Kadim
dc.contributor.authorTuzun, Yekta
dc.contributor.authorDursun, Mehmet
dc.contributor.authorCanoruc, Fikri
dc.date.accessioned2024-04-24T17:33:10Z
dc.date.available2024-04-24T17:33:10Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To compare the effect of intravenous and oral omeprazole in patients with bleeding peptic ulcers without high-risk stigmata. METHODS: This randomized study included 211 patients [112 receiving iv omeprazole protocol (Group 1), 99 receiving po omeprazole 40 mg every 12 h (Group 2)] with a mean age of 52.7. In 144 patients the ulcers showed a clean base, and in 46 the ulcers showed flat spots and in 21 old adherent clots. The endpoints were re-bleeding, surgery, hospital stay, blood transfusion and death. After discharge, re-bleeding and death were reevaluated within 30 d. RESULTS: The study groups were similar with respect to baseline characteristics. Re-bleeding was recorded in 5 patients of Group 1 and in 4 patients of Group 2 (P = 0.879). Three patients in Group 1 and 2 in Group 2 underwent surgery (P = 0.773). The mean length of hospital stay was 4.6 +/- 1.6 d in Group 1 vs 4.5 +/- 2.6 d in Group 2 (P = 0.710); the mean amounts of blood transfusion were 1.9 +/- 1.1 units in Group 1 vs 2.1 +/- 1.7 units in Group 2 (P = 0.350). Four patients, two in each group died (P = 0.981). After discharge, a new bleeding occurred in 2 patients of Group 1 and in 1 patient of Group 2, and one patient from Group 1 died. CONCLUSION: We demonstrate that the effect of oral omeprazole is as effective as intravenous therapy in terms of re-bleeding, surgery, transfusion requirements, hospitalization and mortality in patients with bleeding ulcers with low risk stigmata. These patients can be treated effectively with oral omeprazole. (c) 2006 The WJG Press. All rights reserved.en_US
dc.identifier.endpage7843en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue48en_US
dc.identifier.pmid17203530
dc.identifier.scopus2-s2.0-33846247772
dc.identifier.scopusqualityQ1
dc.identifier.startpage7837en_US
dc.identifier.urihttps://hdl.handle.net/11468/20501
dc.identifier.volume12en_US
dc.identifier.wosWOS:000243309900019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOral Omeprazoleen_US
dc.subjectPeptic Ulceren_US
dc.subjectBleedingen_US
dc.titleA head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clotsen_US
dc.titleA head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots
dc.typeArticleen_US

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