In case of obesity, longevity-related mechanisms lead to anti-inflammation

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dc.contributor.authorKaya, Mehmet Salih
dc.contributor.authorBayiroglu, Fahri
dc.contributor.authorMis, Leyla
dc.contributor.authorKilinc, Dide
dc.contributor.authorComba, Bahat
dc.date.accessioned2024-04-24T16:02:28Z
dc.date.available2024-04-24T16:02:28Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model. Experimental obesity was promoted in a total of 32 young (2 months old) and 32 aged (16 months old) male Wistar albino rats through 8-week cafeteria diet (salami, chocolate, chips, and biscuits). Old and young animals were divided into groups each consisting of eight animals and also divided into four subgroups as obese control, obese food restriction, obese probiotic-fed and obese exercise groups. Probiotic group diet contained 0.05 %w/total diet inactive and lyophilized Lactobacillus casei str. Shirota. The exercise group was subjected to treadmill running 1 h/day, at 21 m/min and at an uphill incline of 15 % for 5 days a week. Food restriction group was formed by giving 40 % less food than the others. The control group was fed regular pellet feed ad libitum. This program was continued for 16 weeks. Blood samples from all the groups were analyzed for fasting glucose, insulin, IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3), interleukin (IL)-6, IL-12, malondialdehyde (MDA), fT3, TT3, fT4, TT4, and liver tissue MDA levels were measured. All applications showed anti-inflammatory effects through the observed changes in the levels of IGFBP-3, IL-6, and IL-12 in the young and old obese rats. While the interventions normally contribute to longevity by recruiting different action mechanisms, anti-inflammatory effect is the only mode of action for all the applications in the obesity model.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)-Agriculture, Forestry and Veterinary Research Support Group research grants [TOVAG-106O344]; Yuzuncu Yil University Grant Commission of research [YYU-BAP-2006-SBE-105]en_US
dc.description.sponsorshipThis study was supported by both the Scientific and Technological Research Council of Turkey (TUBITAK)-Agriculture, Forestry and Veterinary Research Support Group research grants (TOVAG-106O344) and Yuzuncu Yil University Grant Commission of research numbered with YYU-BAP-2006-SBE-105.en_US
dc.identifier.doi10.1007/s11357-013-9598-8
dc.identifier.endpage687en_US
dc.identifier.issn0161-9152
dc.identifier.issn1574-4647
dc.identifier.issue2en_US
dc.identifier.pmid24306820
dc.identifier.scopus2-s2.0-84898912268
dc.identifier.scopusqualityN/A
dc.identifier.startpage677en_US
dc.identifier.urihttps://doi.org/10.1007/s11357-013-9598-8
dc.identifier.urihttps://hdl.handle.net/11468/14802
dc.identifier.volume36en_US
dc.identifier.wosWOS:000333048600014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAge
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectFood Restrictionen_US
dc.subjectExerciseen_US
dc.subjectProbiotic Bacteriaen_US
dc.subjectLongevityen_US
dc.subjectYoung And Aged Ratsen_US
dc.titleIn case of obesity, longevity-related mechanisms lead to anti-inflammationen_US
dc.titleIn case of obesity, longevity-related mechanisms lead to anti-inflammation
dc.typeArticleen_US

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