Evaluation of biological effects induced by diagnostic ultrasound in the rat foetal tissues

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dc.contributor.authorKaragoz, Irfan
dc.contributor.authorBiri, Aydan
dc.contributor.authorBabacan, Figen
dc.contributor.authorKavutcu, Mustafa
dc.date.accessioned2024-04-24T16:02:17Z
dc.date.available2024-04-24T16:02:17Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evaluate in vivo effects of ultrasound exposure of variable duration (from 10 up to 20 min) with commercially available imaging systems commonly used for diagnostic imaging. Numerical results related to the thermal effect are obtained by simulation program based on B-mode (scanning) and Doppler (non-scanning). To investigate the biological effects of the ultrasound exposure to the brain and liver tissues, the antioxidant enzyme activity and thiobarbituric acid reactive substances (TBARS) of the tissues were evaluated. In liver tissue, as a lipid peroxidation index, TBARS levels very significantly increase in Doppler group compared to control. However, in B-mode, TBARS levels are the same with the control group. Use of B-mode in foetal tissue is more reliable than Doppler mode because temperature rise is very small compared to the Doppler mode. On the other hand, the antioxidant enzyme activities tend to increase in B-mode and Doppler groups compared to the control group as a defensive mechanism. In the brain tissue, lipid peroxidation is increased slightly in B-mode compared to the control group. This situation is related to the molecular structure of the brain tissue because of its high lipid concentration. In brain tissue, the antioxidant enzyme activities and lipid peroxidation were significantly increased, such as liver tissue in Doppler groups. Doppler ultrasound may produce harmful effects in rat foetus liver and brain tissues as a result of the high temperature rises.en_US
dc.identifier.doi10.1007/s11010-006-9262-z
dc.identifier.endpage224en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16855790
dc.identifier.scopus2-s2.0-33846687979
dc.identifier.scopusqualityQ1
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-006-9262-z
dc.identifier.urihttps://hdl.handle.net/11468/14726
dc.identifier.volume294en_US
dc.identifier.wosWOS:000243621500025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUltrasounden_US
dc.subjectThermal Effecten_US
dc.subjectBiological Effecten_US
dc.subjectEnzymeen_US
dc.subjectFoetal Tissueen_US
dc.titleEvaluation of biological effects induced by diagnostic ultrasound in the rat foetal tissuesen_US
dc.titleEvaluation of biological effects induced by diagnostic ultrasound in the rat foetal tissues
dc.typeArticleen_US

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