The protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsion

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dc.contributor.authorDokucu, AI
dc.contributor.authorÖztürk, H
dc.contributor.authorÖzdemir, E
dc.contributor.authorKetani, A
dc.contributor.authorBüyükbayram, H
dc.contributor.authorYücesan, S
dc.date.accessioned2024-04-24T16:24:06Z
dc.date.available2024-04-24T16:24:06Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective To investigate histological changes in the contralateral testis of rats with unilateral testicular torsion and the protective effects of nitric oxide (NO) on possible damage. Material and methods Twenty-eight prepubertal male Sprague-Dawley rats were divided into four equal groups. Group 1 underwent a sham operation of the right testis under general anaesthesia. Group 2 underwent a similar operation but the right testis was rotated 720 degrees clockwise for 6 h, maintained by fixing the testis to the scrotum, and saline infused during the procedure. Group 3 underwent similar torsion but L-arginine methyl ester (a precursor of NO) was infused during the procedure. In Group 4, N-G-nitro-L-arginine-methyl ester, a NO synthase inhibitor, was infused separately during the administration of L-arginine methylester and torsion. All the left (untwisted) testes were removed from rats 21 days after surgery and evaluated histologically, assessing seminiferous tubule diameter, loss of sperm and spermatids, loss of germ cell layers, disarray of germ cell layers, rupture of tubules, Leydig cell proliferation and reaction in the ruptured tubules, and oedema. Results There was a significant difference in the indicators of histological damage between groups 2 and 4 and groups 1 and 3, except for the Leydig cell reaction in the ruptured tubules and oedema. The damage was significantly less in group 3 than in groups 2 and 4. Conclusion These results suggest that long-term histopathological changes in the contralateral testes are important after unilateral testicular torsion and that NO has a protective effect on the contralateral testis.en_US
dc.identifier.doi10.1046/j.1464-410x.2000.00529.x
dc.identifier.endpage771en_US
dc.identifier.issn1464-4096
dc.identifier.issue6en_US
dc.identifier.pmid10759681
dc.identifier.scopus2-s2.0-0034126003
dc.identifier.scopusqualityQ1
dc.identifier.startpage767en_US
dc.identifier.urihttps://doi.org/10.1046/j.1464-410x.2000.00529.x
dc.identifier.urihttps://hdl.handle.net/11468/16493
dc.identifier.volume85en_US
dc.identifier.wosWOS:000086446100034
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofBju International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular Torsionen_US
dc.subjectContralateral Testisen_US
dc.subjectNitric Oxideen_US
dc.subjectL-Nameen_US
dc.subjectPrepubertal Raten_US
dc.titleThe protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsionen_US
dc.titleThe protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsion
dc.typeArticleen_US

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