Neutrophil gelatinase-associated lipocalin as a screening test in prostate cancer

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dc.contributor.authorMuslu, Necati
dc.contributor.authorErcan, Bahadir
dc.contributor.authorAkbayir, Serin
dc.contributor.authorBalci, Senay
dc.contributor.authorOvla, H. Didem
dc.contributor.authorBozlu, Murat
dc.date.accessioned2024-04-24T17:27:32Z
dc.date.available2024-04-24T17:27:32Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Prostate specific antigen (PSA) with digital rectal examination is used for diagnosis of prostate cancer (PCa), where definite diagnosis can only be made by prostate biopsy. Recently neutrophilgelatinaseassociated lipocalin ( NGAL), a lipocalin family member glycoprotein, come into prominence as a cancer biomarker. This study is aimed to test serum NGAL as a diagnostic biomarker for PCa and discriminate PCa from benign prostatic hyperplasia (BPH). Material and methods: In this prospective study, 90 patients who underwent transrectal ultrasound- guided 12-core prostate biopsy between May 2015 and September 2015, were evaluated. Histopathologically diagnosed 45 PCa and 45 BPH patients were enrolled in this study. Serum NGAL and PSA levels of all participants were measured, then these data were evaluated by statistical programs. Results: When sensitivity fixed to 80% specificity of NGAL was better than PSA (49%, 31% respectively). Receiver operating characteristic (ROC) curve analysis showed that NGAL alone or its combined use with PSA have better area under curve (AUC) results than PSA alone (0.662, 0.693, and 0.623 respectively). Conclusion: In conclusion NGAL gave promising results such as increased sensitivity and a better AUC values in order to distinguish PCa from BPH. NGAL showed a potential to be a non-invasive biomarker which may decrease the number of unnecessary biopsies.en_US
dc.identifier.doi10.5152/tud.2016.08941
dc.identifier.endpage35en_US
dc.identifier.issn2149-3057
dc.identifier.issue1en_US
dc.identifier.pmid28270948en_US
dc.identifier.startpage30en_US
dc.identifier.trdizinid290347en_US
dc.identifier.urihttps://doi.org/10.5152/tud.2016.08941
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/290347
dc.identifier.urihttps://hdl.handle.net/11468/20027
dc.identifier.volume43en_US
dc.identifier.wosWOS:000400712100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectCanceren_US
dc.subjectHypertrophyen_US
dc.subjectNgalen_US
dc.subjectProstateen_US
dc.subjectPsaen_US
dc.titleNeutrophil gelatinase-associated lipocalin as a screening test in prostate canceren_US
dc.typeArticleen_US

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